alexa Indeno[1,2-b]indoles: A Good Scaffold For Designing Bioactive Molecules
ISSN: 2161-0444

Medicinal Chemistry
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

5th International Conference on Medicinal Chemistry & Computer Aided Drug Designing and Drug Delivery
December 05-07, 2016 Phoenix, USA

Marc Le Borgne
University Lyon 1, France
Keynote: Med chem
DOI: 10.4172/2161-0444.C1.026
Abstract
Indeno [1, 2-b] indoles represent an important class of synthetic compounds for exploring drug targets. The great interest of these structures in Drug Design is due to the use of various building blocks to get the elemental four ring structure. Depending on the synthetic route chosen, the medicinal chemists can also achieve a large number of pharmaco-modulations. Therefore, this presentation aims (i) to present an overview on how to access this family of heterocyclic compounds and (ii) to discuss their various biological applications in oncology (e.g. protein kinases and phosphatases) and in chemoresistance (e.g. ABC transporters). New biological investigations will be also presented. The presentation will cover several scientific disciplines to highlight our drug discovery program dedicated to indeno[1,2-b]indoles. For example, organic syntheses (classical chemical process, “greener” methods), structural optimizations, CE-assay, Autodisplay technology, crystallography, docking, SAR and 3D-QSAR studies, rational design, complexation studies of cyclodextrins, cytotoxicity studies and so on will be presented and discussed. The audience could notice how a research project started, made progress and allowed to build a ChemBio partners’ network to share knowledges and results. Furthermore the success will depend on how chemists interfere with biologists. Both must investigate in all areas at the interface of chemistry and biology.
Biography

Marc Le Borgne has completed his PhD from Nantes Atlantic University after Pharmacy studies (6 years). He is the Director of EA 4446 B2MC, a research group dedicated to Drug Design, Synthesis and Structural Optimization. He has published more than 60 papers in reputed journals and is serving as an Editorial Board Member of Pharmaceuticals (since 2016). He gave some invited lectures abroad He is developing bioactive small molecules targeting kinases, efflux pumps and CYPs. His research interests include design, synthesis and structural optimization of functionalized small molecules as anticancer agents (CK2, Dyrks), efflux pump inhibitors (Pg-p, BCRP) and anti-infective agents (CYP51, vaccines).

Email: [email protected]

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version