alexa Inductor Of Neurotrophic Factors, 4-methylcatechol, Exerts Antidiabetic Effects
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

16th Global Diabetes Conference & Medicare Expo
March 22-23, 2017 Rome, Italy

S Yagubova, K Taraban and R Ostrovskaya
V V Zakusov State Institute of Pharmacology, Russia
Posters & Accepted Abstracts: J Diabetes Metab
DOI: 10.4172/2155-6156.C1.064
Abstract
4-methylcatechol (4-MC) was reported to increase the content of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). Proceeding from the data on neurotrophic factors deficiency in pancreatic beta-cells as important pathogenetic factors of diabetes, we studied the effects of 4-MC on streptozotocin (STZ) induced model of diabetes on Wistar male rats. Animals were divided into 5 groups: passive control (saline), active control (saline+STZ), group of prophylaxis (Pro: 4-MC+STZ), group of treatment (T: STZ+4-MC) and group of combined administration (PT: 4-MC+STZ+4-MC). 4-MC was used in doses of 10 mg/kg for 14 days, STZ as a single injection 45 mg/kg i.p. 4-MC reduced the STZ-induced hyperglycemia, its effect was more pronounced in case of preventive administration, while in passive control we got glucose level 6.83±1, STZ increased it up to17.38±2.19 (p<0.05). Pro group demonstrated glucose level 8.97±0.76 (p<0.05 compared to active control). STZ decreased the percentage of the animals ability to reach the active avoidance criterion to 36.4% from 71.4% in the passive control; rats pretreated with 4-MC successfully learned in 57%. Data obtained demonstrate 4-MC ability to attenuate the hyperglycemia and cognitive deficit caused by diabetogenic toxin STZ.
Biography

S Yagubova is currently working with the group of V V Zakusov Institute of Pharmacology, Moscow, Russia. This group is working with the problem of neurotrophic factors insufficiency in the pathogenesis of diabetes and accompanying by behavioral disorders. Their correction with original peptide mimetics of NGF and BDNF designed in this Institute is also in the focus of this group activity.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords