alexa Infection Of The Central Nervous System Due To Cryptococcus Spp. Complex: An Analysis From A Tertiary Neuro Care-centre In South India
ISSN: 2161-0703

Journal of Medical Microbiology & Diagnosis
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

International Conference on Medical and Clinical Microbiology
July 03-04, 2017 Bangkok, Thailand

Shayanki Lahiri Mukhopadhyay, Nagarathna Chandrashekar, Veenakumari H Bahubali, Netravathi Manjunath, Marimuthu P, Sayani Maji and Satishchandra P
National Institute of Mental Health and Neuro Sciences, India
ScientificTracks Abstracts: J Med Microb Diagn
DOI: 10.4172/2161-0703-C1-008
Abstract
Background & Aim: Cryptococcus neoformans sensu lato, and its sister species C. gattii sensu lato are often cause of meningitis or meningoencephalitis among immunocompromised patients. We aimed to analyse the clinical and epidemiological features of cryptococcal CNS infection. Methods: The study, conducted from 2013 to 2015, included 160 cases of CNS infection due to C. neoformans/gattii. The variables documented were age, gender, immunological status, associated comorbidities, brain-imaging features, CSF parameters and geographical distributions, treatment and outcome. Diagnosis was based on India ink preparation, cryptococcal antigen detection and culture. Statistical analysis was performed by Chi Square Exact test in SPSS 22.0 to determine the P values. Results: Out of 160 cases studied, 128 (80%) were HIV positive. Among the 32 (20%) HIV negative cases 17 (53.1%) had history of immunosuppression. Age group ranged from 2 to 75 years, with mean age of 37.5 years (σ = 9.83) among HIV positive and 36.68 years (σ = 29.16) among HIV negative cases. Other than HIV, tuberculosis was the most common associated comorbidity (28.12%). Headache was predominant complaint (88.8%) followed by vomiting (61.9%), fever (60%), neck stiffness (55.6%). Imaging features were normal in 57 (35.6%) cases followed by presence of hypodense parenchyma (20.6%), meningeal enhancement (18.8%), cortical atrophy (15.6%), and cryptococcal lesion (9.4%). Parameters including neck stiffness (P = 0.021), muscle weakness (P= 0.046) polymorphonucleocyte predominance in CSF (P= 0.012), low sugar (P= 0.038) and high protein (P = 0.003) levels in CSF were significantly different among HIV positive and negative cases. Out of 160 isolates, 142 were C. neoformans s.l. (VNI, VNII) and 18 were C. gattii s.l. (VGI, VGIV, VGIII). Statistical analysis showed molecular type of cryptococcal isolates were dependent on immune status of the patients (P = 0.00001). Conclusion: This study investigates the clinical aspects of cryptococcal infection among Indian patients and contributes to better prognosis and treatment.
Biography

Shayanki Lahiri Mukhopadhyay is doing her research on cryptococcal meningitis for four years. Cryptococcal disease has turned out as the most common and fetal secondary infection in immune-compromised patients in South India. That is why she has designed her research to investigate the clinical and environmental isolates of Cryptococcus neoformans species complex to identify the major environmental sources of the infection, the antifungal susceptibility, pathogenesis of the clinical and environmental isolates to analyze the risks of the infection. Her studies will contribute to the global epidemiology and understanding of virulence of C. neoformans spp. complex, which in turn will help to ease the treatment of cryptocococcal meningitis patients.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords