This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Infectomics is a holistic and integrative study of microbial infection using systems biology and omic approaches.
The conventional wisdom in medicine holds that microbial infection is a pathogenic process (one-way
approach). Our previous studies suggest that symbiosis (Sym) and pathogenesis (Pat) is a duality problem of
microbial infection, including HIV/AIDS and other infectious diseases caused by various microorganisms. The
dynamic Sym-Pat duality is the two-way paradigm of microbial infection, which is the most fundamental issue
of infectomics. Here we propose that the balance between exo-symbiosis (e.g, microbiota) and endosymbiosis
(e.g., mitochondria) is essential for our health and that the exo-endo Sym imbalance plays an important role in
the pathogenesis of infectious diseases, including HIV/AIDS. It is well known that both microbial translocation
across the gut barrier (disturbing exo-symbiosis) and mitochondria-mediated apoptosis (dysregulation of
endosymbiosis) are involved with the pathogenesis of HIV/AIDS. However, the mechanistic connection between
exo-symbiosis and endosymbiosis is unknown. Both exo-symbiosis and endosymbiosis have been implicated
in the development and functions of the immune system. Our model suggests that the exo-endo Sym balance
is fundamental to ecoimmunity, where the immune system and microbial communities are viewed as two
interrelated and dynamically co-evolving components of a predator-prey ecosystem. Correction of disorders of
the ecoimmunity in patients with AIDS may lead to a rational control of HIV infection. Holistic and integrative
studies of ecoinfectomes, ecoimmunomes, and microbiome are important for our understanding of microbial
pathogenesis and the development of symbiotic solutions to infectious diseases.
Sheng-He Huang graduated with a major in Molecular Biology and Medicine from Peking Union Medical College (PUMC) and
Chinese Academy of Medical Sciences (CAMS) in 1981. He is an Associate Professor at the Department of Pediatrics, University
of Southern California. He has published more than 75 peer review papers in reputed journals and served as editorial members
of four journals [1. Anti-infective Agents in Medicinal Chemistry. (AIA-MC); 2. Journal of Data Mining in Genomics & Proteomics
(JDMGP); 3. Open Journals of Applied Sciences (OJAPPS); and 4. Journal of Scientific Research Report (JSRR)].
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals