alexa Inflammation Is Associated With Cardiovascular Disease And Psychiatric Disorders
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

4th International Conference on Clinical & Experimental Cardiology
April 14-16, 2014 Hilton San Antonio Airport, TX, USA

Angelos Halaris
Accepted Abstracts: J Clin Exp Cardiolog
DOI: 10.4172/2155-9880.S1.021
Abstract
Cardiovascular disease (CVD) and depressive illness are two of the world?s leading health problems. CVD is the leading cause of mortality worldwide and accounts for approximately 16.7 million deaths every year. The most common types of CVD are coronary artery disease (CAD) and cerebrovascular disease (CBVD). CAD is a leading cause of morbidity and mortality in the industrialized world and it is the leading cause of death and hospital admissions in the United States. The co- morbidity between CVD and depression is remarkably high and is believed to be bidirectional. Numerous studies published over the past decades have confirmed this association and established that clinical depression is a significant risk factor for mortality in patients with coronary heart disease. Several pathophysiological mechanisms are held responsible for the high co-morbidity between CVD and depression. In this presentation we will focus on inflammation-related parameters in attempting to shed some light on the biology underlying this co-morbidity. Inflammation is intricately related to endothelial dysfunction, atheromatosis, atherosclerosis and atherothrombosis with the associated clinical sequelae that lead to high morbidity and mortality. Over the past two decades, a number of circulating compounds have been identified as markers of inflammation and atherosclerosis. Such compounds include acute-phase proteins, C-reactive protein (CRP), fibrinogen, immunoglobulins, adhesion molecules, and cytokines. We focus on inflammation biomarkers, because most all of these biomarkers have also been shown to be abnormally regulated in patients with depressive syndromes without any evidence of other inflammatory processes, cardiovascular or immune system pathology. Fibrinogen, CRP and from within the cytokine group tumor necrosis factor alpha (TNF-α), interleukin-1 (IL-1) and interleukin-6 (IL-6) have been discussed extensively in the cardiovascular literature and some authors have made a case that CRP and depression have prognostic value in predicting adverse cardiac events. It is widely recognized that inflammatory processes in the atherosclerotic artery may lead to increased blood levels of pro- inflammatory cytokines and other acute-phase reactants. Blood levels of IL-6 and CRP are elevated in patients with myocardial infarction or unstable angina, as are other inflammatory biomarkers, such as fibrinogen, IL-7, IL-8 and soluble CD40 ligand. These findings point to inflammation in the coronary arteries. Collectively, these circulating biomarkers indicate the presence of an acute coronary syndrome and may reflect the clinical course of the condition. Heart failure is a serious syndrome that interferes with normal functioning and significantly impairs the capacity of an individual to lead a normal life. Although several models have been proposed to understand the pathophysiology of this syndrome, none have, so far, proven to be critical for the prevention and management of this condition. The co-morbidity with clinical depression in patients with different degrees of heart failure is high. Taken together, it is now well established that patients with CVD and patients with depressive illness have in common a number of pathophysiologic processes, notably inflammation, that account in large part of the exceptionally high co-morbidity between these disease entities
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_h[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords