alexa Inhibition Of Il-23p19 Signaling Suppresses Osteosarcoma Growth In Vivo
ISSN: 2161-0533

Orthopedic & Muscular System: Current Research
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

3rd International Conference and Exhibition on Orthopedics & Rheumatology
July 28-30, 2014 DoubleTree by Hilton Hotel San Francisco Airport, USA

Maya Kansara, Tiffany Pang, Kevin Mills, Mark Smyth and David M Thomas
ScientificTracks Abstracts: Orthop Muscul Syst
DOI: 10.4172/2161-0533.S1.016
Abstract
Osteosarcoma is the third most common cancer in the adolescent population and has a second peak incidence in those over fifty years of age. Patients are commonly treated with aggressive surgery and intensive adjuvant chemotherapy. The five-year survival of those with metastatic or recurrent disease is less than 25%, which has remained unchanged over the past 30 years. There is a critical need to identify new therapeutic targets for the clinical management of osteosarcoma. IL-23 is a pro-inflammatory cytokine composed of the IL-23p19 and IL-12/23p40 subunits and is expressed by activated dendritic cells and phagocytic cells. To investigate the role of IL-23 in the development of osteosarcoma, Il-23p19 -/- and wildtypemice were injected with radioactive calcium ( 45 Ca), a low energy β -emitter that localizes to bone. Wild-type mice all developed osteosarcomas at 18-24 months after exposure to radiation (median survival was 80.7 weeks and 100% had osteosarcomas by 90.7 weeks), whereas 24/30 (80%) of Il-23p19-/- mice were strikingly disease free at 2 years of age ( P<0.0001 ). Primary mouse and human osteosarcoma were found to express high levels of IL-23A compared to normal human bone by in situ hybridization and quantitative PCR. Using a preclinical allograft mouse model of osteosarcoma, preliminary studies indicate that neutralizing antibody to IL-23 can suppress tumor growth and prolong survival. This is the first study to show a critical role for IL-23 in osteosarcoma development and suggests that targeting this inflammatory cytokine has clinical utility in the treatment of primary tumors and in an adjuvant setting for osteosarcoma.
Biography
Maya Kansara completed her PhD at Otago University in New Zealand. Currently she is working as a research fellow at the Peter MacCallum Cancer Centre, Melbourne, Australia in the laboratory of Prof David Thomas. She is the lead investigator for the osteosarcoma program in the laboratory and has expertise in a wide range of cellular, and molecular techniques, as well as experience with primary cell culture and preclinical mouse models. Her aim is to identifynovel therapeutic targets in osteosarcoma.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords