alexa Inhibition Of Phospholipase A2 Of Naja Nigricollis By Oleanolic Acid Acetate From Cryptolepis Oblongifolia
ISSN: 2329-6836

Natural Products Chemistry & Research
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5th International Conference and Exhibition on Pharmacognosy, Phytochemistry & Natural Products
July 24-25, 2017 Melbourne, Australia

Saifullahi Umar, Bashir Zubairu Chedi, Garba Ibrahim, Ahmed Abubakar and Balarabe Abdullahi Sallau
Bayero University Kano, Nigeria
Ahmadu Bello University, Nigeria
Posters & Accepted Abstracts: Nat Prod Chem Res
DOI: 10.4172/2329-6836-C1-017
Abstract
Cryptolepis oblongifolia (Meisn.) Schltr. is a shrub, traditionally used in treatment of snakebite. Column chromatography of ethyl acetate extract yielded an isolate which was tested against purified phospholipase A2 of Naja nigricollis venom. The 1HNMR spectra of the isolate revealed present of eight quaternary methyl while the 13CNMR indicate carboxylic acid and carbonyl ester signals, by comparison with literature the isolate was found to be oleanolic acid acetate which inhibit phospholipase A2 in a dose dependent fashion with inhibition binding constant ki 1.7 μg/ml. The relevance of these finding could serve as bases for the development of antivenin.
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