alexa Inhibitors Of The HIF Pathway And Novel Therapeutic Opportunities
ISSN: 2161-1025

Translational Medicine
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

2nd International Conference on Translational & Personalized Medicine
August 05-07, 2013 Holiday Inn Chicago-North Shore, IL, USA

Mridul Mukherji
ScientificTracks Abstracts: Transl Med
DOI: 10.4172/2161-1025.S1.008
Abstract
Hypoxia plays critical roles in the pathobiology of heart disease, cancer, stroke, eye, and chronic lung disease, which are responsible for 60% of deaths in the United States. Hypoxia-mediated activation of the hypoxia-inducible-factor (HIF) pathway, leading to transcriptional changes in gene expressions, plays a fundamental role in the pathobiology of above diseases. Yet, molecular and biochemical mechanisms governing this fundamental pathway remain poorly understood. Since our initial identification of first iron(II), 2-oxoglutarate (2OG)-dependent dioxygenase involved in transcription regulation by the HIF pathway, results from numerous studies have established a key role for these enzymes in epigenetic transcriptional regulation. Our long term goal is to use our experience in the HIF pathway and dioxygenases/demethylases to delineate their roles in normal development/disease states, and identify small molecule modulators that can be used to develop more effective strategies for therapeutic intervention. We have recently shown that hypoxia induces the expression of a number of histone lysine demethylases/ dioxygenases (KDMs) in cancer and retinal pigment epithelial cells. Moreover, we found that the expression of pro-angiogenic genes (ADM and GDF15) is dependent on KDMs under hypoxic conditions. Further, treating the cells with a general KDM inhibitor blocks the expression of these pro-angiogenic genes. Results from our studies suggest that specific inhibitors of KDMs such as JMJD1A can be a new therapeutic approach to treat diseases caused by the hypoxia.
Biography
Mridul Mukherji has completed his D.Phil. (Ph.D.) at the age of 29 years from the University of Oxford and postdoctoral studies from the Scripps Research Institute. At present, he holds a rank of Assistant Professor at the School of Pharmacy, University of Missouri-Kansas City. He has published more than 26 papers in reputed journals and serving as an editorial board member of Dataset Papers in Biology, Hindawi Publishing Corporation.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version