alexa
Reach Us +44-1202068036
Inhibitory Effect Of Cetrorelix On Thiotepa Induced Folliculogenesis Disturbances | 19929
ISSN: 2155-9864

Journal of Blood Disorders & Transfusion
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

2nd International Conference on Hematology & Blood Disorders

Ramouz A, Mohammadnejad D and Hosseini M
Accepted Abstracts: J Blood Disorders Transf
DOI: 10.4172/2155-9864.S1.008
Abstract
Objective: Infertility problem affects 20?30 % of young couples. One of the known causes of oogenesis disorder is chemotherapy in patients with cancer. Since dividing cells are mainly affected by anticancer drugs, the aim of the present study is investigating the preventive effect of GnRH on oogenesis defect produced by anticancer drug. Material and Methods: In the present study 30 adult female mice aging 6-8 weeks were used. The mice were divided into 3 equal groups as control, exp group 1 and exp group 2. In exp. group 1 Thiotepa were injected as ip for 5 days at 2.5 mg/kg. In exp group 2, cetrorelix injection was started one week before thiotepa treatment and continued for 3 more weeks. The mice in all groups were sacrificed 3weeks after the last dose of cetrorelix injection. Ovaries specimens were prepared for LM studies. Results: Microscopic study revealed that in the control group the mean number of primordial, primary, secondary and tertiary follicles were 1184?214, 241?26, 58?14, 42?7 respectively. In exp group 1 the mean number of above mentioned follicles were 629?180, 202?25, 39?7, 19?2 respectively but in the exp 2 group the mean number of above mentioned follicles were 1033?128, 231?30, 55?13, 38?8.The data showed the difference between control and exp 1 group was significant, but the difference between control and exp. 2 was not. Conclusion: It?s concluded GnRH antagonist administration before cancer treatment could prevent the side effect of anticancer drugs.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri and Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version