alexa Innovative And Strategic Materials For Medical Technology Against Tumors: Preclinical Researches On Sugar Dendritic Gd-DTPA Complex MRI Contrast Agents And IER5/Cdc25B Targeted Novel Phospha Sugar Antitumor Agents
ISSN: 2161-0444

Medicinal Chemistry
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

5th International Conference on Medicinal Chemistry & Computer Aided Drug Designing and Drug Delivery
December 05-07, 2016 Phoenix, USA

Mitsuji Yamashita
Shizuoka University, Japan
Keynote: Med chem
DOI: 10.4172/2161-0444.C1.026
Abstract
Novel and high sensitive sugar dendritic Gd-DTPA complexes for tumor diagnosis and novel multiple type and wide spectral antitumor agents of low-molecular-weight phospha sugar derivatives which target IER5/Cdc25B to innovate in chemo-therapeutic treatments against various type of cancer cells were investigated. Sugar dendritic Gd-DTPA complex DENOH was prepared. The in vivo evaluation of DEN-OH for MRI contrast agent showed quite clear images of blood vessels as well as very early stage of cancer. Phospha sugars having a phosphorus moiety in the hemiacetal ring of the Harworth equation of sugars were prepared from phosphorus heterocycles by new synthetic methods to construct the compound library. And their preclinical evaluations and mechanistic investigations were carried out. Branched deoxybromo-phospha sugar derivatives such as DBMPP and TBMPP were found to exert novel, potential, and wide spectral antitumor activities by MTT in vitro evaluation method. The characterization and mechanism elucidation of these phospha sugar derivatives by flow cytometry and Western blotting showed that DBMPP and/or TBMPP enhanced the expression of cancer suppressors and suppressed the expression of cancer accelerators. TBMPP showed very high antitumor activity against blood cancer cells (K562, U937, etc.) as well as solid cancer cells and the IC50 value against various kind of leukemia cells were almost the same values. TBMPP enhanced the expression of IER5 and then suppressed the expression of Cdc25B, which is the common and essential factor to act at the mitosis stage of tumor cell cycles. Therefore, phospha sugar derivatives might induce apoptosis at G2/M stage and inhibit the proliferation of various kinds of cancer cells (or stem cells of leukemia might be attacked by phospha sugars). In vivo evaluation for TBMPP against K562 cells transplanted to a nude mouse implied successful cure of cancer. Based on the preclinical research and computer aided drug designing we are expecting that phospha sugars may be developed to be clinically useful novel and innovative antitumor agents.
Biography

Mitsuji Yamashita has completed his PhD in 1972 from Nagoya University, Japan, and Post-doctoral studies from Toyota Science and Chemistry Research Center, Japan, and Iowa State University, USA. He was a visiting professor of University of Massachusetts at Amherst, USA, and a visiting researcher of Oxford University, UK, in 1994. He started his studies on phospha sugars in 1973 and promoted to be a Professor of Shizuoka University, Japan, in 1996 and retired at the age of 65 years to be a professor emeritus of Shizuoka University, Japan. His research field is now focused on medicinal materials based on chemistry of carbohydrates and phosphorus compounds to develop phospha sugar antitumor agents and sugar dendritic Gd-DTPA MRI contrast agents so as to be clinical use for innovating in cancer therapy. He has published more than 180 papers and patents as well as four books.

Email: [email protected]

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords