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Insilco Analysis Of Translocation Breakpoint Region Of MLL (Mixed Lineage- Leukemia) | 9014
ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
Open Access

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Insilco analysis of translocation breakpoint region of MLL (Mixed Lineage- Leukemia)

3rd International Conference on Proteomics & Bioinformatics

Medha Dave and Rakesh Rawal

Posters: J Proteomics Bioinform

DOI: 10.4172/0974-276X.S1.068

MLL (mixed lineage leukemia) gene, which is one paradigm of leukemogenesis, because it is frequently part of random chromosomal translocations that defines aunique group of acute leukemias in terms of clinical and biological features. In leukemia, MLL function is subverted by rupture, illegitimate recombination, and the formation of a chimeric fusion in which the N-terminal portion of MLL is fused to the C-terminal portion of over 50 alternative partner genes. Cytogenetic abnormalities are characteristics attribute of cancer cells. Several mechanisms including deletions, duplications, translocations etc are involved in formation of chromosomal rearrangements and their role in tumorigenesis. . A more thorough understanding of mechanisms that cause translocations will be aided by continuing characterization of translocation breakpoints. Insilco analysis of frequently occurring translocation breakpoint region of MLL gene was performed. Segmental duplicons were identified on chromosomal bands of both translocation partners. Various physico-chemical parameters were taken into consideration for characterization of chromosomal breakpoint. Result suggests possible role of segmental duplication and these
Medha H Dave has completed her B.Sc in Microbiology and M.Sc in Bioinformatics Subject, She is pursuing her Ph.D. On? In-silico analysis of Chromosomal translocation and Oncogenic Fusion Protein In Leukemia? Since 2010 at Department of Bioinformatics, Maharaja krishnakumarsinhji Bhavnagar University, INDIA. She was working as Teaching Assistant at the same Department. Right now she is also working as part time Visiting Lecturer.
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