alexa
Reach Us +441414719275
Integrated Analysis Of Blood Gene Expression And Biomarker Data To Define Asthma Endotypes In Children | 9390
ISSN: 0974-7230

Journal of Computer Science & Systems Biology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

International Conference on Integrative Biology Summit

Stephen W. Edwards
Accepted Abstracts: J Comput Sci Syst Biol
DOI: 10.4172/0974-7230.S1.004
Abstract
Common diseases such as asthma, diabetes, and atherosclerosis result from a complex mixture of genetic and environmental factors. Much progress has been made on identifying genetic determinants for these diseases, and efforts are currently underway to better characterize environmental contributions (commonly referred to as the exposome). A better understanding of the mechanistically distinct subtypes of common complex diseases is, however, needed to make the best use of these new data streams. We evaluated methods for deriving these mechanistic subtypes using a cross-sectional study stratified on asthmatic and non-asthmatic children from Detroit, MI, in which a wide array of clinical and environmental biomarkers were measured along with blood gene expression. Our integrated analysis of the blood expression and clinical covariates resulted in a recursive partitioning tree that segregated study participants into purely data-driven endotypes based on their asthma status. These endotypes are consistent with previous classifications although our data suggest multiple mechanistically distinct neutrophilic subtypes. Functional characterization of the genes and associated covariates revealed a complex interaction among Th2 mediated lung inflammation, heightened systemic innate immune response, and potentially metabolic syndrome in discriminating asthma endotypes. The results from this study can be used to advance human study designs and analytical methods for investigating both genetic and environmental causes of common diseases to improve prevention, diagnosis, and treatment of these diseases. [This is an abstract or a proposed presentation and does not necessarily reflect EPA policy. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.
Biography
Stephen Edwards is a Systems Biologist within the U.S. Environmental Protection Agency?s National Health and Environmental Effects Research Laboratory (EPA-NHEERL) in Research Triangle Park, N.C. Dr. Edwards is developing a framework to integrate in vitro , lab animal, and biomarker data from target organisms to improve the scientific underpinnings of the Agency?s human and ecological risk assessments. He serves as a senior advisor in the Office of Research and Development (ORD) on issues regarding the development of predictive toxicology models of disease using genomics, proteomics, and metabolomics.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

https://www.gaziantepescort.info

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version