alexa Integrated -omic Approaches To Understand The Adaptations Of Lactococcus Lactis To Zero-growth Conditions | 16238
ISSN: 2153-0769

Metabolomics:Open Access
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

3rd International Conference and Exhibition on Metabolomics & Systems Biology

Onur Ercan,E J Smid and M Kleerebezem
Accepted Abstracts: Metabolomics
DOI: 10.4172/2153-0769.S1.026
Abstract
Extremely low availability of nutrients, especially carbon sources, is a significant challenge for bacteria, not only in natural environments, but also in industrial fermentation processes. An example is the process of cheese ripening, in which lactic acid bacteria in the cheese matrix are depleted from fermentable substrates. Survival under these conditions requires adaptations of cellular metabolism, and coincides with extremely slow or zero-growth of the microorganisms. Zero-growth is defined as metabolically active, non-growing state of a microorganism in which product-formation capability is maintained and thereby is principally different from starvation. Retentostat cultivation system has been designed to simulate zero-growth conditions. Retentostat cultivation is a modification of chemostat cultivation in which the complete biomass is maintained in the fermenter by removing the spent- medium effluent through a retention filter-unit, while the medium is supplied at a fixed dilution rate. Prolonged retentostat cultivation leads to growth rates that approximate zero while the rate of energy transduction equals the maintenance energy requirement. The aim of this study is to examine the physiological and molecular behavior of Lactococcus lactis during the transition from a growing to a zero-growth state using glucose-limited retentostat cultivation. After cultivating L. lactis at extremely low- growth rates in retentostat conditions, cell physiology, metabolic profile, and viability of the culture were investigated. Besides, the genome-wide transcriptome and targeted metabolome patterns were determined to understand the molecular adaptations of the strain under zero-growth conditions. Finally, the transcriptome data allowed identification of transcription signatures that reflect the zero-growth conditions within the extended retentostat cultivation.
Biography
Onur Ercan graduated from the Department of Molecular Biology and Genetics in Istanbul Technical University, Turkey, in 2005 and received his MSc degree in Biotechnology in 2008. He has done his Ph.D. at Laboratory of Microbiology in Wageningen University, the Netherlands. His Ph.D. project was done with the collaboration of Kluyver Centre, TI Food and Nutrition, and NIZO Food Researchers in the Netherlands. He is currently the guest researcher in Wageningen University.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7