alexa Interaction Of Conessine With Resistance-nodulation-division Efflux Pumps In Multidrug-resistant Pseudomonas Aeruginosa Assessed By Hoechst 33342 Accumulations
ISSN: 2161-0703

Journal of Medical Microbiology & Diagnosis
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

JOINT EVENT ON 15th International PHARMACEUTICAL MICROBIOLOGY AND BIOTECHNOLOGY CONFERENCE & 10th Annual MEDICAL MICROBIOLOGY SUMMIT & EXPO
June 21-23, 2017 London, UK

Thanyaluck Siriyong, Peter John Coote and Supayang Piyawan Voravuthikunchai
Prince of Songkla University, Thailand
University of St Andrews, UK
Posters & Accepted Abstracts: J Med Microb Diagn
DOI: 10.4172/2161-0703-C1-006
Abstract
Pseudomonas aeruginosa infections have become increasingly difficult to treat due to intrinsic antibiotic resistance. Overexpression of resistance-nodulation-division (RND) efflux pumps such as MexAB-OprM, MexXY-OprM, MexCD-OprJ, and MexEF-OprN in the pathogen is detected in clinical isolates and contributes to worrying multidrug resistance (MDR) phenotypes. A number of efflux pump inhibitors have been used to restore susceptibility to antibiotics for treating MDR organisms. This study was aimed to determine a steroidal alkaloid compound, conessine as an efflux pump inhibitor against MDR P. aeruginosa strains by measuring the accumulation of a fluorescent dye, Hoechst 33342. Increase in the accumulation of H33342 after treatment with conessine against P. aeruginosa strains was observed indicating that conessine could inhibit efflux pump systems in the pathogen. The finding suggested that conessine might be a potent efflux pump inhibitor with possible utility as an adjunctive therapeutic agent for the treatment of Gram-negative bacterial infections.
Biography

Thanyaluck Siriyong is an Assistant Researcher at the University of St. Andrews, Scotland, UK. She has completed her PhD in Microbiology from Prince of Songkla University, Thailand and received her BSc and MSc in Thai Traditional Medicine from Prince of Songkla University. This work was supported by the Thailand Research Fund through the Royal Golden Jubilee PhD Program co-funded by the British Council through Newton Fund.

Email: Thanyaluck_Si@hotmail.com

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

agriaquaculture@omicsonline.com

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

biochemjournals@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

chemistryjournals@omicsonline.com

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

clinicaljournals@omicsonline.com

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

engineeringjournals@omicsonline.com

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

nutritionjournals@omicsonline.com

1-702-714-7001Extn: 9042

General Science

Andrea Jason

generalscience@omicsonline.com

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

geneticsmolbio@omicsonline.com

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immunomicrobiol@omicsonline.com

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

nursinghealthcare@omicsonline.com

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

medicaljournals@omicsonline.com

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuropsychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

pharmajournals@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords