Diabetic nephropathy is the most important microvascular complication among type 2 diabetic patients. Oxidative stress
plays a major role in the pathogenesis of diabetic nephropathy. The present study investigated the combined effect of Emblica
officialise (EO) with Pioglitazone in type II diabetes induced nephropathy. Diabetes was induced in male Sprague-Dawley rats
with high fat diet fed/low dose STZ injection which induced changes in the renal histopathology with concurrent decrease in
antioxidative enzymes. Altered lipid profile, elevated blood glucose level, serumcreatinine, blood urea nitrogen, proteinuria was
observed in diabetic control. Group I received normal pellet diet (control), group II served as diabetic control and groups III
to V were treated with EO alone, Pioglitazone alone, EO plus Pioglitazone respectively. Treatment schedule was started one day
before STZ injection. Treatment with combination of EO and Pioglitazone significantly attenuated the renal dysfunction when
compared with groups treated alone. The beneficial effect of this combination can be attributed to the amelioration of oxidative
stress induced changes in diabetic renal structure.
Karthik CH has completed his B.Pharm from Bharathi College of Pharmacy, Bharathi Nagara, Karnataka and pursuing his M.pharm from Krupanidhi
College of Pharmacy, Karnataka. He attended many workshops like workshop on patents organised by IIPTA in the 2012. He participated in many
seminars like Seminar on Standardisation of Drugs, organised by RGUHS, Karnataka.
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