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Background: Trauma injury and hemorrhagic shock frequently leads to the imbalance of immune system known as Systemic
Inflammatory Response Syndrome (SIRS) and is connected to the morbidity or mortality. Pro and Anti-inflammatory, which play
a significant role in the development of multiple organ failure (MOF).
Objective: This study investigates the serum cytokines levels in patients with trauma hemorrhagic shock and the association of
these cytokines with clinical outcome.
Design: Prospective cohort study
Patients: A total 70 patients with trauma hemorrhagic shock admitted to the emergency department, level 1trauma centre.
Method: Peripheral blood samples were collected in each patient for determination of serum cytokines concentration. Samples
were obtained within 8 h of post injury with T/HS patients. Standard resuscitation techniques as per Advance Trauma Life
Support were used in each patient. Clinical and laboratory data were prospectively collected.
Results: High concentrations of circulating IL-6, IL-10, IL-8, IL-12, (p< 0.05) were detected in a trauma hemorrhagic shock
as compared with healthy control group. At study entry, IL-8 concentrations were higher in non-survivors as compared with
survivors T/HS patients but not TNF-?, IL-1 ?, IL6, IL10. Increased IL-8 value was an indicator of mortality in patients with
trauma hemorrhagic shock.
Conclusions: In trauma hemorrhagic shock, increased IL-6, IL-10, IL-8, IL-12 are detected while compared to normal healthy
control. In these patients, increased IL-8 value in nonsurvivors as compared to survivors and TNF-?, IL-1 ?, IL6, IL10 do not
correlate with clinical outcome. This study suggests a much higher degree of activation of immune-inflammatory in T/HS than in
normal healthy control. Increased IL-8 values were found to be reliable markers of mortality following T/HS.
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