alexa Intravaginal Delivery Of Polyphenon 60 And Curcumin Nanoemulsion Gel
ISSN 2472-1042

Pharmacoeconomics: Open Access
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

11th World Congress on Pharmaceutical Sciences and Innovations in Pharma Industry
February 27-28, 2017 Amsterdam, Netherlands

Atinderpal Kaur
Jaypee University, India
Posters & Accepted Abstracts: Pharmacoeconomics
DOI: 10.4172/2472-1042.C1.003
Polyphenon 60 (P60) and curcumin (CUR) were loaded in a single nano emulsion system and their combined antibacterial action was studied against uropathogenic Escherichia coli. To enhance bioavailability at target organs and to inhibit enzymatic degradation in gastric intestinal tract, vaginal route of administration was explored. P60+CUR nanoemulsion (NE) was formulated by ultra-sonication and optimized using Box-Behnken design. Optimized NE showed Z-average of 211.2 nm, polydispersity index 0.343 and zeta potential -32.7 mV. Optimized P60+CUR NE was characterized for stability and transmission electron microscopy (TEM) and it was observed that NE was stable at 4ºC for 30 days and monodispersed in nature with particle size in the range of 195-205 nm. P60+CUR NE was further formulated to gel and characterized by viscosity parameters and in-vitro permeation studies. In vitro drug release studies in simulated vaginal media showed maximum release (84±0.21%) of curcumin within 5 h and (91±0.16%) of P60 within 8 h. Both the drugs maintained sustainable release up to 12 h. To investigate the transport via intravaginal route, gamma scintigraphy and biodistribution study of P60+CUR NBG was performed on Sprague-Dawley rats using 99m technetium pertechnetate for radiolabeling to P60 molecule. Following intravaginal administration, P60+CUR NBG dispersed in kidney and urinary bladder with (3.07±0.15) and (3.35±0.45) percentage per gram after 3 h, respectively and remained active for 12 h. Scintigraphy images and biodistribution findings suggested that the P60+CUR NBG given by intravaginal route led to effective distribution of actives in urinary tract to eradicate urinary tract infection.

Email: [email protected]

image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version