alexa Intravaginal Delivery Of Polyphenon 60 And Curcumin Nanoemulsion Gel | 62779
ISSN 2472-1042

Pharmacoeconomics: Open Access
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

11th World Congress on Pharmaceutical Sciences and Innovations in Pharma Industry

Atinderpal Kaur
Jaypee University, India
Posters & Accepted Abstracts: Pharmacoeconomics
DOI: 10.4172/2472-1042.C1.003
Abstract
Polyphenon 60 (P60) and curcumin (CUR) were loaded in a single nano emulsion system and their combined antibacterial action was studied against uropathogenic Escherichia coli. To enhance bioavailability at target organs and to inhibit enzymatic degradation in gastric intestinal tract, vaginal route of administration was explored. P60+CUR nanoemulsion (NE) was formulated by ultra-sonication and optimized using Box-Behnken design. Optimized NE showed Z-average of 211.2 nm, polydispersity index 0.343 and zeta potential -32.7 mV. Optimized P60+CUR NE was characterized for stability and transmission electron microscopy (TEM) and it was observed that NE was stable at 4ºC for 30 days and monodispersed in nature with particle size in the range of 195-205 nm. P60+CUR NE was further formulated to gel and characterized by viscosity parameters and in-vitro permeation studies. In vitro drug release studies in simulated vaginal media showed maximum release (84±0.21%) of curcumin within 5 h and (91±0.16%) of P60 within 8 h. Both the drugs maintained sustainable release up to 12 h. To investigate the transport via intravaginal route, gamma scintigraphy and biodistribution study of P60+CUR NBG was performed on Sprague-Dawley rats using 99m technetium pertechnetate for radiolabeling to P60 molecule. Following intravaginal administration, P60+CUR NBG dispersed in kidney and urinary bladder with (3.07±0.15) and (3.35±0.45) percentage per gram after 3 h, respectively and remained active for 12 h. Scintigraphy images and biodistribution findings suggested that the P60+CUR NBG given by intravaginal route led to effective distribution of actives in urinary tract to eradicate urinary tract infection.
Biography

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]m

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7