alexa Investigation Into Hepatoprotective And Antioxidant Potentials Of Epilobium Hirsutum On Iron Dextran Induced Hepatotoxicity In Sprague Dawley Rat
ISSN: 2376-0419

Journal of Pharmaceutical Care & Health Systems
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10TH Asia-Pacific Pharma Congress
May 08-10, 2017 Singapore

N A Sheikh and T R Desai
KYDSCT’s College of Pharmacy, India
RK University, India
Posters & Accepted Abstracts: J Pharma Care Health Sys
DOI: 10.4172/2376-0419-C1-021
Abstract
Present study deals with investigation of hepatoprotective and antioxidant potentials of E. hirsutum in iron overloaded rats. The hepatotoxicity was induced by administering six IP injections of iron dextran (12.5 mg/100 g) uniformly distributed over a period of 30 days. Different fractions of E. hirsutum were given orally whereas Deferoxamine (DFO) was given subcutaneously for 30 days. The various biochemical parameters were estimated on 15th and 30th days of treatment whereas antioxidant parameters were estimated on 30th day of treatment. The methanolic fraction of methanolic extract (MFME) and methanolic fraction of aqueous extract (MFAE) of E. hirsutum significantly (P<0.01) decreases Superoxide Dismutase (SOD), Catalase (CAT) and Glutathione (GSH) whereas significantly (P<0.01) increases Malondialdehyde (MDA) as compared to the disease control (DC) rats. There were significant (P<0.01) hepatoprotective effects shown by MFME and MFAE of E. hirsutum. Hence present study concluded that MFME and MFAE of E. hirsutum have hepatoprotective and antioxidant effect. The possible mechanism of action as hepatoprotective may be due to its antioxidant potential by scavenging free radicals through iron chelation.
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