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Alzheimer?s disease (AD) differs from other forms of dementia in its relation to amyloid beta peptide
(A☐42). Using a cell culture model we previously identified annexin A5, a Ca2+ and phospholipid binding
protein, as an AD biomarker. Plasma level of annexin A5 was significantly higher in AD patients compared to that
in a control group. As AD shares clinical and pathological features with Dementia with Lewy bodies (DLB), the
present study was done to examine the similarity of AD and DLB using the plasma AD biomarker annexin A5.
Hitoshi Sohma completed his Ph.D. in biochemistry at Hokkaido University, Japan, focusing on Ca2+-signaling in cell-cell
communications, and his postdoctoral studies at the National Institute of Mental Health, NIH. He is a professor in the Department
of Educational Development, Sapporo Medical University Center for Medical Education, Sapporo, Japan. He is also involved in
both pathobiochemical research and the management of medical education at the university.
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