alexa Investigation Of Antioxidant Effect On Chemically Induced Breast Cancer Model
ISSN: 2161-0444

Medicinal chemistry
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

3rd International Conference on Medicinal Chemistry & Computer Aided Drug Designing
December 08-10, 2014 DoubleTree by Hilton Hotel San Francisco Airport, USA

Mehmet Ozcan, Merve Bacanli, Mojtaba Beyramzadeh, Gunes Esendagli and Yasemin Aksoy
Posters: Med Chem
DOI: 10.4172/2161-0444.S1.012
Abstract
Glutathione transferase P1-1 (GST P1-1) is often overexpressed in tumor cells and is regarded as a contributor to their drug resistance. The available literature contains a limited of strong GST P1-1 inhibitors. Additionally, in vivo studies of these inhibitors are very restricted because of their highly toxic effects. Therefore, the most potent and comparatively less harmful GST P1-1 inhibitors seem to be an attractive target for drug development. The aim of this study is to evaluate the protective effects of chlorophyllide as an antioxidant molecule which has inhibitory effects on GST P1-1 on chemically-induced breast cancer model. For this purpose, N-methyl-N-nitrosourea (MNU) was used for inducing carcinogenesis in eighteen, 21-dayold female Sprague-Dawley rats. MNU and chlorophyllide solutions were injected intraperitoneally when the rats were 21, 28, 35 and 42 days old. Their weight and tumor diameters were measured throughout 5 months. At the end of the study, all animals were sacrificed and determined DNA damage in blood, organs and tumor tissues. According to the preliminary data, chlorophyllide treatment significantly decreased the DNA damage in tissues and blood. However, after tumorigenesis, we observed that it promoted tumor growth. The measurement of glutathione levels, GST and antioxidant enzymes activity in organ and tumor tissue are underway.
Biography
Mehmet Ozcan graduated from Cukurova University, Department of Chemistry and he is a master student and research assistant at Medical Biochemistry Department of Hacettepe University in Turkey. His research interests are in the following areas: Glutathione S-tranferase, Enzyme Kinetics, Drug Designing, Cell Culture and Experimental Animals.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords