Investigation Of Antioxidant Effect On Chemically Induced Breast Cancer Model | 24177
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Glutathione transferase P1-1 (GST P1-1) is often overexpressed in tumor cells and is regarded as a contributor to their drug
resistance. The available literature contains a limited of strong GST P1-1 inhibitors. Additionally, in vivo studies of these
inhibitors are very restricted because of their highly toxic effects. Therefore, the most potent and comparatively less harmful
GST P1-1 inhibitors seem to be an attractive target for drug development. The aim of this study is to evaluate the protective
effects of chlorophyllide as an antioxidant molecule which has inhibitory effects on GST P1-1 on chemically-induced breast
cancer model. For this purpose, N-methyl-N-nitrosourea (MNU) was used for inducing carcinogenesis in eighteen, 21-dayold
female Sprague-Dawley rats. MNU and chlorophyllide solutions were injected intraperitoneally when the rats were 21,
28, 35 and 42 days old. Their weight and tumor diameters were measured throughout 5 months. At the end of the study, all
animals were sacrificed and determined DNA damage in blood, organs and tumor tissues. According to the preliminary data,
chlorophyllide treatment significantly decreased the DNA damage in tissues and blood. However, after tumorigenesis, we
observed that it promoted tumor growth. The measurement of glutathione levels, GST and antioxidant enzymes activity in
organ and tumor tissue are underway.
Mehmet Ozcan graduated from Cukurova University, Department of Chemistry and he is a master student and research assistant at Medical Biochemistry
Department of Hacettepe University in Turkey. His research interests are in the following areas: Glutathione S-tranferase, Enzyme Kinetics, Drug Designing, Cell
Culture and Experimental Animals.
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