alexa Investigation Of Cellular Response To Ionising Radiation: Value Of Different Model Systems And Strategies Of Irradiation
ISSN: 1948-5956

Journal of Cancer Science & Therapy
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4th World Congress on Cancer Science & Therapy
October 20-22, 2014 DoubleTree by Hilton Hotel Chicago-North Shore Conference Center, USA

Su?iedelis Kęstutis, Norkus Darius, Rotomskis Ričardas, Did?iapetriene Janina and Valuckas Konstantinas Povilas
Accepted Abstracts: J Cancer Sci Ther
DOI: 10.4172/1948-5956.S1.035
Abstract
The results of radiotherapy of different cancer cases suggest the development of radioresistant tumors and confirm the need in the advanced understanding of radiobiology of tumors. Investigations using 3D cell cultures are expected to result in more successful oncology clinical trials which based on 2D models not representing complexity of tumors currently fail up to 90%. Therefore we have employed 3D cell culture model to investigate cellular response to ionizing radiation. Single or fractionated dose irradiation of 2Gy, 10Gy and 5x2Gy have been used. Global gene and miRNA expression changes after irradiation have been analyzed by transcriptomics analysis in Lewis lung carcinoma (LLC1) cell line cells cultured in 2D or 3D. Cell response of tumor tissue to irradiation is under investigation in an animal model to demonstrate if/which cell culture model better reflects cell radiobiology in vivo. In addition nanotechnologies are applied to increase or decrease the cellular sensitivity to ionising radiation. Potential of applied techniques to result in the development of more efficient strategies of anticancer radiotherapy under evaluation. The results of cancer patients treatment strategies derived from experimental research will be presented.
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