alexa Investigation Of Chemoprevention Properties Of Halopteris Scoparia Brown Algae By Using In Vivo Bioluminescent Imaging
ISSN: 1948-593X

Journal of Bioanalysis & Biomedicine
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

7th European Biosimilars Congress
May 15-16, 2017 Munich, Germany

Ozgenur Erdokur, Adem Guner, N Ulku Karabay Yavasolu and Yeliz Yildirim
Ege University, Turkey
Posters & Accepted Abstracts: J Bioanal Biomed
DOI: 10.4172/1948-593X-C1-027
Abstract
Cancer disease causing uncontrolled cell division is one of the crucial research areas. Cancer types such as lung, prostate, stomach, colon, and over are most common. Chemoprevention as the use of natural or synthetic chemicals to prevent from cancer disease has been investigated by several groups in the literature. There are a lot of scientific discovery about natural product agents such as vegetables, fruits, mushrooms, yeast, fungi, algae for potential new anticancer drugs. Algae survive in a large scale in the earth: in the sea, rivers, and lakes, on the land, on the other organism. Some bioactive compounds obtained from seaweeds have the ability to inhibit the growth of different cancer cells. They can be employed as cancer chemopreventive and/or chemotherapeutic agents. In this study, in vivo anticancer effects of Halopteris scoparia Sauvageau (brown algae) as an anti-cancer drug has been evaluated against A549 human lung cancer cells. H.scoparia was collected at a depth of 1-2 m, from the coastline of Urla, Izmir, in April 2012. The samples were washed three times with tap water and maintained in a refrigerator at -20°C. Five-week-old male nude mice were divided into three groups: control, 900 mg/kg algae treatment (everey day, p.o.) and 2 mg/kg cisplatin treatment (twice a week, i.p). A549- luciferase human lung cells (1-2 x 106 cells/site) were injected subcutaneously into the left or right side of the mice legs. Anti-cancer properties of H. scoparia algae were examined by using bioluminescence imaging (IVIS spectrum) during four weeks with tumor volume and animal weight measurements. In vivo bioluminescence imaging uses luciferase enzymes as reporters to generate light emission during the catalytic oxidation of their substrates for noninvasive imaging of biological targets and processes in living animals. Consequently, the results show that anti-cancer activity of H. scoparia is similar to cisplatin which is used commonly chemotropic agent.
Biography

Özgenur Erdokur was born in Bursa on 2 Nisan 1993. She studied at Ege University, Faculty of Science, Department of Chemistry between 2011 to 2016. She has participated in various congresses such as participating the organizing committee of the 6th National Chemistry Students Congress and the in vivo cancer imaging course which organized in 2015 in Ege University, Center for Drug Research & Development and Pharmacokinetic Applications (ARGEFAR). She has started her postgraduation since 2016 in Ege University, Division of Physical Chemistry and also worked in ARGEFAR. a charge of the In Vivo Imaging Sistem (IVIS) device with my supervisor Assoc.Prof.Dr.Yeliz Yıldırım who is consultant of device which is located in Prephase research unit of ARGEFAR. IVIS has many uses, and their laboratory has a wide range of applications. There are a lot of project continue in their laboratory especially cancer disease, so she has worked on these issues many times. The Prephase imaging and bio-similarity researches are of great importance for the drug development process.

Email: [email protected]

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version