alexa Investigation Of Human CA1-induced Toxicity In The Drosophila Model Of Motor Neuron Degeneration | 24126
ISSN: 2161-0444

Medicinal Chemistry
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

3rd International Conference on Medicinal Chemistry & Computer Aided Drug Designing

Jian Liu
ScientificTracks Abstracts: Med Chem
DOI: 10.4172/2161-0444.S1.011
Abstract
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig?s disease, is one of the neurodegenerative diseases that affect motor neuron function leading to paralysis and fatal death. Mechanisms of ALS pathogenesis remain elusive. Carbonic anhydrase I (CA1) was recently discovered to be altered in ALS patients. Whether and how CA1 might be involved in ALS pathology is completely unknown. Our study demonstrated for the first time that CA1 was expressed in spinal cord motor neurons. We further established Drosophila model of CA1-induced motor neuron degeneration and investigated molecular mechanisms of pathology. Our results showed: 1) Expression of human CA1 in Drosophila motor neurons caused locomotion defect in both larval and adult flies without affecting lifespan; 2) Impairment of larval locomotion is correlated with reduced numbers of boutons and branches at NMJs, while preliminary data also indicated that the number of adult motor neurons was decreased by CA1 expression. 3) CA inhibitor acetazolamide ameliorated larval locomotion defect in Drosophila suggesting that carbonic anhydrase activity was required for the toxicity. Results from our studies provide potential new drug targets and design for therapeutic treatment of ALS.
Biography
Jian Liu has completed her PhD in Neuroscience from Washington University and postdoctoral studies from University of California, San Diego.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7