Investigation Of Polymorphic Variants Of SLC6A4, Tph-1 And Tph-2 Genes In Completed Suicide | 57261
Journal of Forensic Research
Like us on:
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Suicide is a big health problem in the world. Studies have shown that suicidal behavior has psychiatric, sociological, economic and
biological causes. In this thesis project, possible relationship between suicidal behavior and genetic structure was analyzed. Studies
in the literature have shown that serotonergic system affects the behaviors of people. Hence, polymorphic variant of rs1800532,
rs7305115, rs6355, rs1386494 regarding TPH-1, TPH-2 and SLC6A4 genes having important roles in serotonin production and
degradation pathways were selected for analysis. 100 completed suicide samples and 100 healthy control samples were included in
this study. Age (18-65) and the gender distribution were selected to be similar in suicide and control groups. Absence of psychiatric
disorder history other than depression, schizophrenia, bipolar mood disorder, mental retardation, chronic illness, drug and alcohol
addiction were noted in sample selection. DNA isolation was made from blood samples and then polymorphic variants, rs6355,
rs1800532, rs7305115, rs1386494, of TPH-1, TPH-2 and SLC6A4 genes were analyzed by KASP (Competitive Allele Specific PCR)
method. No significant difference in gender and age distribution was observed between suicide and control groups. Our results
showed that genotype and individual allele frequencies of polymorphic variants (rs1800532, rs7305115, rs6355, rs1386494) were not
significantly different in two groups. In conclusion, no association between TPH-1, TPH-2 and SLC6A4 gene polymorphisms was
observed in completed suicide samples.
Duygu Yavuz received her undergraduate degree in Biology at Hacettepe University in Ankara, Turkey. She is studying for her Master’s degree in Forensic Biology at Forensic Science Institute, Ankara University. She is expected to receive the degree at the end of July. This study is her thesis project.