Ionotropic Glutamate Receptors (iGluR) are important in development and functions of nervous system and are implicated
in the etiology of various dysfunctions like Alzheimer?s, Parkinson?s and Neurolathyrism. This receptor mediate excitatatory
synaptic transmission through ligand induced opening of transmembrane ion channels. In this study we employed the molecular
modeling approach to explore the binding affinities of glutamate and β-ODAP (β-N-oxalyl-L,α,β-diamino propionic acid) with
the (iGluRs) by using Accelrys Drug Discovery suite. The molecular modeling studies revealed promising binding interactions of
these ligands with the iGluRs amino terminal domain (PDB ID: 3SAJ). The ligand ? target model generated by Discovery studio is
validated by Ramachandran plot in PROCHECK analysis. The results obtained suggests a novel mechanism by which the amino
terminal domain of iGluRs participating in these interactions.
Amol L. Shirfule has completed his Ph.D at the age of 29 years from S.R.T.M.University and postdoctoral studies at Food & Drug Toxicology
Research Centre, National Institute of Nutrition, I.C.M.R., Govt. of India. He has published more than 6 papers in reputed journals and serving as a
Post Doctoral Associate at National Institute of Nutrition.
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