IRF5, PTPN22, CD28, IL2RA, KIF5A, BLK andTNFAIP3 genes polymorphisms and lupus susceptibility in a cohort from the Egypt delta; relation to other ethnic groups

3^rd International Conference on Genomics & Pharmacogenomics

September 21-23, 2015 San Antonio, USA

Ashraf Antar Elghzaly

Mansoura University, Egypt

Posters-Accepted Abstracts: J Mol Genet Med

Abstract :

Objective: To replicate a single nucleotide polymorphism (SNP) of known genes for lupus (IRF5rs10488631, PTPN22rs2476601, BLKrs2736340 and TNFAIP3rs5029939) and other autoimmune diseases (CD28rs1980422, IL2RArs2104286 and KIF5Ars1678542) on a newly studied Egyptian cohort to investigate the genetic disparity with different studied ethnic groups in relation to lupus susceptibility. Methods: 170 Egyptian patients from Egypt Delta with SLE and 241 matched healthy controls were genotyped by Taqman real time PCR for the selected SNPs. Results: The results revealed significant association withIRF5 (p<0.0001) and PTPN22 (p=0.008) and insignificant association with KIF5A, CD28, IL2RA, BLK and TNFAIP3 genes. Conclusions: This study may provide an additional evidence for the association between IRF5 and PTPN22 and lupus susceptibility and may exclude it for CD28, IL2RA and KIF5A.

Biography :

Email: drashrafantar@mans.edu.eg