alexa Irradiation Of Mouse Mammary Gland Stimulates The Migration Of Triple Negative Breast Cancer Cells And Development Of Lung Metastases
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

4th World Congress on Cancer Science & Therapy
October 20-22, 2014 DoubleTree by Hilton Hotel Chicago-North Shore Conference Center, USA

Benoit Paquette, Gina Bouchard, Genevi?ve Bouvette, H?l?ne Therriault, Rachel Bujold, and Caroline Saucier
ScientificTracks Abstracts: J Cancer Sci Ther
DOI: 10.4172/1948-5956.S1.033
Abstract
Emergence of migratory phenotype is believed to be the consequence of acquired mutations in cancer cells. Alone, this mutation-based hypothesis cannot explain the progression of all tumors. Since inflammation can be associated with the promotion of metastases, it is important to determine whether radiation-induced inflammation in healthy breast could stimulate the migration of cancer cells and ultimately favor the formation of metastases. Our study was done with the D2A1 breast cancer cells which are triple negative (TNBC), a subgroup of breast cancer at higher risk of early recurrence. A single mammary gland of Balb/c mice was irradiated with 4 fractions of 6 Gy given at 24h interval. After the last irradiation, D2A1 breast cancer cells were implanted close to the nipple. This protocol eliminated confounding effects that could occur by irradiating the tumor and the mammary gland at the same time, such as selection of a subpopulation of cancer cells that could be more likely to migrate. Pre-irradiation of mammary gland before implantation increased the migration of cancer cells, the quantity of circulating cancer cells and the number of lung metastases. These adverse effects were associated with induction of pro-inflammatory molecules such as COX-2 and IL-6. In conclusion, we propose an alternative mechanism to explain the higher risk of early recurrence for TNBC based on pro-migratory molecules induced by radiation.
Biography
Benoit Paquette is a radiobiologist who studies the biological consequences of radiation therapy. His research is oriented towards improving radiotherapy for brain and breast cancer, as well as preventing cancer cell invasion induced by radiation. His team has pioneered the use of the Gamma Knife for irradiating localized patches of cortex in rodents. Two clinical trials based on results obtained in his laboratory are currently underway in brain tumor patients. He is the Director of the Department of Nuclear Medicine and Radiobiology, University of Sherbrooke, and he is the Vice-president of the International Society of Radiobiology in French Language.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords