alexa Is Tooth Extraction A Risk Factor For HCV Infection? Studying RNA And Genotypes
ISSN: 2161-0517

Virology & Mycology
Open Access

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10th World Congress on Virology and Mycology
May 11-12, 2017 Singapore

Mustafa Waseem Al-Kubaisy, Waqar Al-Kubaisy, Nik Shamsidah N I and Redhwan Al-Naggar
Ministry of Health, Iraq
Posters & Accepted Abstracts: Virol-mycol
DOI: 10.4172/2161-0517-C1-021
Abstract
Background: Hepatitis C virus (HCV) is a major public health problem, it has been estimated that 130-200 million people worldwide are infected. The medical risk factor associated with HCV infection such as blood transfusion and surgery had been intensely studied in many countries. Up to 40% of HCV patients may have non identifiable routes of viral acquisition. Tooth extraction may be one of these risk factors. The purpose of the present study was to determine the existence of infection and the predominated HCV genotype among subjects with tooth extraction. Material & Methods: A case-control study was conducted involving 776 pregnant women with and 2715 without history of tooth extraction. HCV antibodies (anti-HCV) were tested using subsequently third generation enzyme immunoassay (EIA-3) and immunoblot assay (Lia Tek-111). In addition, 94 serum samples were subjected to molecular analysis using RT-PCR and DNA enzyme immunoassay (DEIA) method for HCV-RNA and genotypes. Results: Positive anti-HCV rate was significantly higher (6.3%) among women with tooth extraction (cases) than their counter group (control) (2.63%) (p=0.00001). Tooth extraction act as significant risk factor for HCV infection (OR=2.73; 95% CI=1.8-3.9). HCVRNA was found to be significantly higher (74.6%) in cases than (38.7%) control group (p=0.0016). No significant association between HCV genotypic and the history of tooth extraction but HCV-1b showed higher rate (90%) among tooth cases. Conclusion: Our study showed that tooth extraction acts as a risk factor for acquiring HCV. Complete sterilization and cleaning of equipment is necessary.
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