alexa Keratoconus Progression In Pediatric Patients With Allergy And Elevated Surface Matrix Metalloproteinase 9 Point-of-care Test Vs. Negative Patients
ISSN: 2155-9570

Journal of Clinical & Experimental Ophthalmology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

2nd Global Pediatric Ophthalmology Congress
June 05-06, 2017 Milan, Italy

Cosimo Mazzotta
University of Siena, Italy
ScientificTracks Abstracts: J Clin Exp Ophthalmol
DOI: 10.4172/2155-9570-C1-060
Abstract
Purpose: To assess keratoconus (KC) progression in pediatric patients with allergies who tested positive to surface matrix metalloproteinase 9 (MMP-9) point-of-care tests versus negative patients. Methods: Prospective comparative study including 100 stage I-II keratoconic patients, mean age 15. All patients underwent an anamnestic questionnaire for concomitant allergic diseases and were screened with the MMP-9 point-of-care test. Patients were divided into 2 groups: KC patients with allergies (KC AL) and KC patients without allergies (KC NAL). Severity of allergy was established by papillary sub-tarsal response grade (PSR) and keratoconus progression assessed by corneal tomography, and corrected distance visual acuity (CDVA) measurement in a 12-month follow-up. Results: The KC AL group included 52 patients and the KC NAL group 48. In the KC AL group 42/52 of patients (81%) were positive to MMP-9 point-of-care test vs. 2 positive patients in the KC NAL group (4%). The KC AL group data showed a statistically significant decrease of average CDVA, from 0.155±1.1 to 0.301±1.2 log MAR (p<0.005) at 12 months; K max value increased significantly, from 50.2 D±2.7 to 55.2 D±1.9 on average. The KC NAL group revealed a slight keratoconus progression without statistically significant changes. Person’s correlation test showed a high correlation between K max worsening and severity of PRG in the KC AL group. Conclusions: The study demonstrated a statistically significant progression of KC in pediatric patients with concomitant allergies, positive to MMP-9 point-of-care test vs. negative. A high correlation between severity of allergy and keratoconus progression was documented.
Biography

Cosimo Mazzotta has done his MD from School of Medicine, University of Siena, Italy in the year 1997. He did a Specialist Diploma in Ophthalmology in 2001 and has received his PhD in Ocular Pathology in 2006. He introduced the Corneal Cross Linking in Italy in 2004 being awarded by the Italian Society of Ophthalmology. In 2009, he became the Assistant Professor of Corneal Surgery at Optometry School of University of Siena, Italy. Currently, he is an Assistant Professor of Corneal Pathology and Surgery at Post-graduate Ophthalmology School of Siena University and Director of the Siena International Crosslinking Center. His areas of interest include corneal cross-linking, keratoconus, corneal transplants, corneal dystrophies, cataract and refractive surgery, and in vivo confocal microscopy.

Email: [email protected]

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version