alexa
Reach Us +1-217-403-9671
Kidney, The Major Organ In The Body To Evaluate Toxic And Transport Properties Of Environmental Chemicals | 8382
ISSN: 0975-0851

Journal of Bioequivalence & Bioavailability
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Kidney, the major organ in the body to evaluate toxic and transport properties of environmental chemicals

International Conference & Exhibition Bioequivalence and Bioavailability

Sivakumar Gowder

ScientificTracks Abstracts: Bioavailability & Bioequivalence

DOI: 10.4172/0975-0851.1000001

Abstract
F or the past many decades, humans have experienced significant changes in diet and lifestyles. Environmental and lifestyle factors play a major role in human disease. Nephrotoxicity is the common side effect of environmental insults. Physiological and biochemical features of the kidney make it more sensitive to environmental chemicals. Large blood flow, presence of metabolizing enzymes and transporters are the important factors for the sensitivity of the kidney. Although biomarkers for nephrotoxicity are available, improved biomarkers could contribute greatly to the monitoring of renal injury after exposure to environmental toxicants. Biochemical and pathological studies of the kidney will reveal toxicity of chemicals at certain extent. Culturing of good quality renal proximal tubule cells derived from known segments of the nephron provides an important model to evaluate toxicity. Transport studies will reveal the quality of the proximal tubules while in toxicity. Exposure to nephrotoxicants induces ET-1 production that leads to a rapid decrease in transport activity. Excessive ET-1 formation may cause renal injury and many renal diseases are associated with elevated ET-1 levels. A specific group of enzymes of the cytochrome-P-450 family in the kidney can be induced by environmental chemicals and this can be evaluated through micro array technology. Thus, kidney is the major organ to evaluate toxic and transport properties and also the mechanism of toxicity of environmental chemicals.
Biography
Top