alexa Linking Tissue Micro Architectures To Rationalized Molecular Diagnostics In Glandular Cancers
ISSN: 2153-0645

Journal of Pharmacogenomics & Pharmacoproteomics
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

2nd International Conference on Predictive, Preventive and Personalized Medicine & Molecular Diagnostics
November 03-05, 2014 Embassy Suites Las Vegas, USA

Kelvin K Tsai
ScientificTracks Abstracts: J Pharmacogenomics Pharmacoproteomics
DOI: 10.4172/2153-0645.S1.002
Abstract
Disruption of tissue microarchitectures represents an early step of epithelial tumorigenesis and the degree of which has been widely used for the histopathological grading of glandular cancers. Molecular portraits of structural differentiation may identify key regulatory pathways and improve outcome prediction in human glandular cancers. To translate this concept to clinics and to facilitate patient-tailored cancer treatment decision, we performed comparative genomic analysis of glandular microarchitectures generated in a three-dimensional organotypic culture system which recapitulated the differentiated morphology and exocrine functions of human glandular epithelial tissues to identify differentiation and microarchitecturespecific gene signatures. This knowledge-based and model-informed biomarker strategy allows us to develop a highly accurate and robust 6-gene molecular diagnosis which can reflect tumor differentiation and cancer stem cell activity, thereby enabling a rationalized classification and prognostic prediction of pancreatic cancer patients. Similarly, we developed a 6-gene microarchitecture-specific signature which can prognostically classify prostate cancer patients with a remarkable accuracy. Thus, by exploiting the genomic program associated with glandular microarchitecture formation, we can identify differentiation-specific molecular subtypes and related prognostic markers that significantly enhance prognostic prediction of human glandular cancers. This strategy is now being used to develop differentiation-specific biomarkers in other types of glandular cancers that have high pathogenetic significance and clinical utility.
Biography
Kelvin K Tsai completed his MD from Taipei Medical University and his PhD from Harvard University and Postdoctoral studies from University of California, San Francisco. He is currently the Associate Investigator and attending Physician at National Institute of Cancer Research, a NIH-equivalent research institute in Taiwan. He is the author of more than 20 papers in high-impact basic and translational research journals and several issued or pending patents.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version