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Lately, it has been brought to light that if white adipose tissues could possibily be turned into brown fat it would certainly play
critical role in curtailing down many disease pathogenesis. To understand what really happens on muscle cells when it turns
to white adipose tissue, we investigated the adipogenic differentiation of mouse L6 myoblasts by combining two adipogenic
inducers i.e. Linolenic acid (LA) and Thiazolidinedione (TZD). The L6 myoblast cells near confluence were selected to initiate
the treatment with adipose induction mixture. While LA (100 uM) + TZD (10 uM) treatments were given after exposure with
adipogenic induction mixture at every 48 hours and the samples were collected on d 0, 5 and 10. Significant adipogenesis were
revealed with Oil-Red-O staining itself. However, higher genetic expressions of PPARγ, Adipo Q and LPL as well as the intense
immunostaining of PPAR-
further confirmed that initially when muscles gets converted it first turns into white
adipose tissue. In conclusion, we realized that white adipose tissues formed during different pathological situation needs to be
converted to brown adipose tissue to contain pathological process in the biological system.
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