Liver Stiffness Predicts Relapse After Direct Acting Antiviral Therapy Against Chronic Hepatitis C Virus Infection | 109230
Journal of Infectious Diseases & Therapy
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Introduction & Objective: Assessment of fibrosis in chronic hepatitis has always been considered of utmost
relevance for patient care in clinical hepatology. Over the last years, multiple non-invasive methods were
used for diagnosis of hepatic fibrosis, including transient Elastography in addition to clinical and biochemical
parameters or combinations of both methods. Serum markers and elastography are considered useful
techniques for diagnosing severe liver fibrosis and cirrhosis and for excluding significant fibrosis in hepatitis
C virus infected patients. Also, liver stiffness may help to foretell treatment response to antiviral therapy. The
objective of this study is to evaluate changes of Transient elastography values as well as serum fibronectin and
AST to Platelet Ratio Index in patients (APRI) treated with Sofosbuvir-based treatment regimen.
Method: This is a follow-up study including 100 chronic HCV Egyptian patients treated with Sofosbuvirbased
treatment regimen. Transient elastography values were recorded as well as serum fibronectin and APRI
were calculated at baseline and SVR12.
Results: There was a significant improvement of platelets counts, ALT and AST levels, which in turn cause
significant improvement in APRI scores at SVR12. Liver stiffness measurements were significantly lower at
SVR12 (15.40±8.96 vs. 8.82±4.74 kPa, P=0.000). There was significant decline in serum fibronectin from
baseline to SVR 12 (524.14±237.61 vs. 287.48±137.67, P=0.000).
Ghweil Ali Abdelrahman was a Resident of (Tropical medicine and Gastroenterology) for three years .He worked as a Clinical demonstrator and assistant lecturer of Tropical medicine and Gastroenterology, Sohag University. He was working as a Lecturer of Tropical medicine and Gastroenterology, South Valley University. Currently, he is the Head of Tropical Medicine and Gastroenterology department, South Valley University. He is also a member of the European Society of Liver Diseases (EASL).
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