alexa Localized Regulated Expression Of IL-12 As A Gene Therapy Approach To Cancer Immunotherapy
ISSN: 2157-7633

Journal of Stem Cell Research & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

3rd International Conference and Exhibition on Cell & Gene Therapy
October 27-29, 2014 Embassy Suites Las Vegas, USA

John A Barrett
ScientificTracks Abstracts: J Stem Cell Res Ther
DOI: 10.4172/2157-7633.S1.007
Abstract
Tumors escape the immune system through the process of immunoediting. Thus, restoration of the immune system?s ability to detect the tumor should result in an improved treatment outcome. Localized IL-12 administration elicits antitumor activity mediated by direct tumor cell cytotoxicity and enhancement of immuno-regulatory activities. We have developed an adenoviral vector, Ad-RTS-mIL-12, administered intratumorally under the control of the RheoSwitch Therapeutic System? expression platform. Gene expression and subsequent IL-12 production is tightly controlled by the oral administration of the activator ligand veledimex. We have shown on mechanism biologic activity and safety with this system in syngeneic mouse models of melanoma and breast cancer. Ad-RTS-mIL-12 (1x1010)+ veledimex elicited a dose-related increase in tumor IL- 12mRNA and IL-12 protein leading to increased tumor influx of natural killer, CD4+ and CD8+ T cells with corresponding reduction in tumor growth. A return to baseline IL-12mRNA and IL-12 protein was observed on veledimex withdrawal. Approximately 1% of veledimex crosses the blood brain barrier in naive mice and cynomolgus monkeys increasing to 6% in orthotopic mice. In the orthotopic mouse model Ad-RTS-mIL-12+veledimex demonstrated a dose-related increase in survival devoid of adverse safety effects. At Day 100 (study termination) ~50% of the Ad-RTS-mL-12+veledimex 450mg/ m2/day (Qdx14) survived. Survival correlated with marked decreases in tumor stem cells. In ongoing Phase 2 clinical trials in melanoma and breast cancer we have observed immune responses and biologic activity. In summary, this novel regulated immunotherapeutic approach could potentially be translated into an effective clinical regimen for the treatment of melanoma, breast and glioblastoma.
Biography
John A Barrett has completed his PhD from Saint John?s University, NY. He is presently Vice President of R&D and Head of Translational Research at Ziopharm Oncology with a research focus in immunotherapy, oncology, targeted radiopharmaceuticals and biomarkers. During his career, he was responsible for numerous IND?s and NDA?s and has authored 45 papers in peer review journals.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords