alexa Long Noncoding RNA Or3a4 Promotes Metastasis And Tumorigenicity In Gastric Cancer
ISSN: 2157-7552

Journal of Tissue Science & Engineering
Open Access

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Global Congress on Tissue Engineering, Regenerative & Precision Medicine
December 1-2, 2016 | San Antonio, USA

Xiaobo Guo
University of Shandonity, China
Posters & Accepted Abstracts: J Tissue Sci Eng
DOI: 10.4172/2157-7552.C1.031
Abstract
The contribution of long noncoding RNAs (lncRNAs) to metastasis of gastric cancer remains largely unknown. We used microarray analysis to identify lncRNAs differentially expressed between normal gastric tissues and gastric cancer tissues and validated these differences in quantitative real-time (qRT)-PCR experiments. The expression levels of lncRNA olfactory receptor, family 3, subfamily A, member 4 (OR3A4) were significantly associated with lymphatic metastasis, the depth of cancer invasion, and distal metastasis in 130 paired gastric cancer tissues. The effects of OR3A4 were assessed by overexpressing and silencing OR3A4 in gastric cancer cells. OR3A4 promoted cancer cell growth, angiogenesis, metastasis, and tumorigenesis in vitro and in vivo. Global microarray analysis combined with RT-PCR, RNA immunoprecipitation, and RNA pull-down analyses after OR3A4 transaction demonstrated that OR3A4 influenced biologic functions in gastric cancer cells via regulating the activation of PDLIM2, MACC1, NTN4, and GNB2L1 . Our results reveal OR3A4 as an inorganic lncRNA that promotes tumor progression; therefore, lncRNAs might function as key regulatory hubs in gastric cancer progression.
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