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|Hemchandracharya North Gujarat University, India|
|ScientificTracks Abstracts: Endocrinol Metab Syndr|
|Objective: To study the pharmacological evaluation of Lonicera japonioca with reference to metabolic syndrome in order to restore 11β-HSD1 induced endothelial dysfunction in SD rats. Introduction: Metabolic syndrome is multidisciplinary metabolic disorder in which Diabetes Mellitus, Hypertension and Obesity are presented jointly. Chlorogenic acid is a major bioactive component in the flower buds of Lonicera japonica having 11β-HSD1 property. 11β-HSD1 induced endothelial dysfunction has been postulated to be a major contributor to the pathogenesis of Metabolic Syndrome. Methods: Present studies were aimed towards investigating the effectiveness of this LJALE extract against STZ-HFD induced diabetes and associated complications, fructose induced hypertension and HFD induced obesity respectively using SD rats. Parameters like ex vivo 11β-HSD 1 inhibition assay, vascular reactivity study, Nitric Oxide and Peroxynitrile have been measured. Results: Chlorogenic acid isolated from LJALE could dose dependently inhibit the 11β-HSD1 activity. LJALE attenuate the 11β-HSD1 induced endothelium dysfunction in rats. LJALE treated obese animal reflect significant increased Nitric oxide and decreased Peroxynitrile. Conclusion: From all above statements, it has been concluded that Lonicera japonica protects SD rats against 11β-HSD1 induced endothelium dysfunction in Metabolic Syndrome.|
Chirag Prajapati has completed his PhD (Pharmacology) in May 2016. He has presented his MPharm research paper in USA in October 2013. He has total 5 years of experience in Academic & Research. He is presently working as a Hospital & Clinical Pharmacist in Government Hospital.
Email: [email protected]
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