alexa Macrophage Polarization: Role Of PPARγ Activation In Chronic Inflammation-associated Breast Cancer | 65291
ISSN: 2153-0769

Metabolomics:Open Access
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

8th International Conference and Exhibition on Metabolomics & Systems Biology

Shreya Kar
National University of Singapore, Singapore
Posters & Accepted Abstracts: Metabolomics
DOI: 10.4172/2153-0769-C1-038
Abstract
The tumor microenvironment is a complex architecture in which the functionally diverse and the heterogeneous macrophages play an important role in tumor growth and metastasis. Macrophages exhibit cellular plasticity and have various subtypes with distinct phenotypic properties depending on the micro environmental "signals". Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcription factor expressed in macrophages and has been shown to promote macrophages to alternatively activated M2 phenotype in various cancers. This is responsible for immunosuppression and tumor growth. However, its effect on macrophage polarization in chronic inflammation-associated breast cancer is not fully understood. Herein, by using murine macrophages and a panel of breast cancer cell lines, we show exposure of macrophages to conditioned media from metastatic breast cancer cell lines prime them to adopt an M2 phenotype with dose-dependent increase in PPARγ expression along with M2 markers. Conversely, inhibition of PPARγ activity reverses this phenotype. Interestingly, treatment of macrophages with PPARγ activators that belong to the drug class of thiazolidinediones (TZDs) enhanced the M2 phenotype which was effectively blocked when used together with a PPARγ-specific antagonist. Therefore, exploring the role of PPARγ in the dynamic process of macrophage polarization and the mechanisms governing this process not only is important for our understanding of the M1–M2 paradigm of macrophage polarization but also provides insights to new treatment strategies via targeting imbalances of macrophage polarization. Moreover, a newer and safer molecule that activates PPARγ is much needed in the clinic as the TZDs do have toxic side effects. To that effect, we have recently set up a collaboration agreement with pharmaceutical company, Daiichi Sankyo USA, for the use of their pipeline Phase II-completed PPARγ activator, CS-7017, in our subsequent studies.
Biography

Email: [email protected]

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version