alexa
Reach Us +441902928240
Macrophage-specific Expression Of Antimicrobial Peptide PR-39 Inhibits Intracellular Growth Of BCG In Mouse Macrophage Cells And Lung | 6692
ISSN: 2157-7633

Journal of Stem Cell Research & Therapy
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Macrophage-specific expression of antimicrobial peptide PR-39 inhibits intracellular growth of BCG in mouse macrophage cells and lung

International Conference on Regenerative & Functional Medicine

XIA Qian-feng, WEN Yang-An, TU Zhi-Guang, QIAN Shi-Yun and QIN Xi

Accepted Abstracts: J Stem Cell Res Ther

DOI: 10.4172/2157-7633.S1.005

Abstract
Objective To construct an adenovirus expression vector encoding antimicrobial peptide PR39 , and to observe its expression and antimicrobial activity in mouse macrophage RAW264.7 cells and lung. Methods Recombinant adenovirus vector pAd- PR39 was used to infect mouse macrophage RAW264.7 cells and lungs and its antimicrobial activity against BCG was detcted. The expression of PR39 gene in mouse macrophage RAW264.7 cells and lungs was detected by immunocytochemistry. Results Recombinant adenovirus Ad-PR39 were infected into macrophage RAW264.7 cells and lung for stable or transient expression of PR-39. PR-39 expression in macrophage cells was subsequently confirmed by immunocytochemistry and showed stronger antibacterial ability against BCG than control group. Conclusion These results demonstrated that macrophage-specific expression of antimicrobial peptide PR-39 in macrophages could inhibit the growth of intracellular BCG and indicated it to be a novel and promising approach for the control of refractory intracellular infection.
Biography
Leave Your Message 24x7
Top