alexa Magnetic Localization Of Drug-loaded Nanoparticles For Tumor Therapy: Pre-clinical Validation | 14514
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

3rd International Conference on Nanotek & Expo

Jim Klostergaard
Keynote: J Nanomed Nanotechnol
DOI: 10.4172/2157-7439.S1.012
Abstract
Breast cancer is the second leading cause of cancer death in women with estimated 2013 incidence of new cases of invasive breast cancer at >230,000 and deaths at ~40,000. Many patients will undergo systemic, multi- drug chemotherapy, including those with locally advanced breast cancer (LABC), or those who fail hormonal modulation and other forms of targeted therapy. Treatment-related adverse events may be experienced by up to 90% of these patients. Thus, demand is growing for targeting methods that enhance therapeutic efficacy while concurrently minimizing associated toxicities. Our proposed nanobiotechnology platform employs an external Magnetic Localization Unit (MLU) to generate focused magnetic field gradients covering the tumor volumes of either superficial orvisceral tumors, to amplify extravasation, via the EPR effect, of magnetically responsive nanoparticles (MNP) carrying a drug payload. MNP-paclitaxel (MNP-TXL) prodrug constructs, based on bioreversible linkages, demonstrated significant anti-tumor efficacy in a human LABC xenograft model, validating the bioreversible linker chemistry; over 40% of treated mice remain cured and have survived for over a year. In pilot toxicology studies, MNP constructs and MNP-TXL prodrug constructs displayed minimal toxicity against 32 different types of normal tissues, including clearance organs. Vizimag tm 2D software visualizations of magnetic field gradients generated by a proprietary MLU comprised of small permanent magnet arrays indicate that sufficiently-powered magnetic field gradients can be generated to meet varying tumor characteristics of size, area, and depth, for both superficial and deep-seated visceral tumors. Thus, essential pre-clinical validation has been achieved for this magnetic nanovector approach for tumor-specific localization of therapeutics
Biography
Jim Klostergaard, Ph.D., joined the University of Texas, MD Anderson Cancer Center in Houston, TX over 30 years ago and currently is Professor in the Department of Molecular and Cellular Oncology and has twice served as chair of the Faculty Senate. His doct oral training was at the Roswell Park Cancer Institute, one of three original Comprehensive Cancer Centers designated in the National Cancer Act of 1971. His post-doctoral training was accomplished at the University of California, Irvine. His current interests are in targeted therapeutics and magnetic drug delivery, and he has more than 110 publications in peer-reviewed journals.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7