alexa Magnetic Resonance Imaging Versus Serum Ferritin Levels In Detection Of Liver And Cardiac Iron Overload In Non-transfusion Dependent Thalassemia
ISSN: 2161-0665

Pediatrics & Therapeutics
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

JOINT EVENT on 11th International Conference on Clinical Pediatrics & 2nd International Conference on Pediatric Surgery
June 29- July 01, 2017 London, UK

Eman Oweida
Mansoura University, Egypt
NMC Royal Hospital, UAE
ScientificTracks Abstracts: Pediatr Ther
DOI: 10.4172/2161-0665-C1-039
Abstract
Background: MRI is now established as the non-invasive modality of choice for the diagnosis of liver iron overload. Recently, it has been used to estimate myocardial iron overload in adult patients with acquired anemia. Objective: to assess the value of gradient-echo T2* in monitoring and screening of both liver and cardiac iron overload in nontransfusion dependent thalassemia (NTDT). Material and methods: This prospective study was conducted on children with mean age 11 years. Measurements were obtained in the same 1.5 MRI examination, followed by calculation with the reference spreadsheet and then, the results were compared to the standard serum ferritin levels. Results: The study included 31 patients with non-transfusion-dependent thalassemia (NTT); 19 with thalassemia-intermedia, 6 with thalassemia-minor and 6 with hemoglobin-H. Mean serum ferritin was 201.8 ng/mL. Mean liver T2* was measured at 23.7 ms. Mean myocardial T2* was measured at 30 ms. Correlation analysis revealed significant negative correlation between hepatic T2* and serum ferritin (P<0.001*, R=-0.8). Week positive correlation was found for cardiac T2* (P=0.04, r=-0.37) and a week negative correlation was between hepatic and cardiac T2* values (P=0.4, R=-0.37). Statistically significant negative correlation with age was detected for hepatic T2* (P=0.001, R=-0.44) but not for cardiac T2* and serum ferritin. Conclusion: liver and cardiac T2* measurement is the non-invasive modality of choice for monitoring and screening of both liver and cardiac iron overload in NTDT. From our experience, cardiac iron overload is uncommon in this disease population even in cases with mild and moderate hepatic overload.
Biography

Eman Oweida has completed her PhD in 2013 in Mansura University, Egypt. She continued working in Mansoura Faculty of Medicine as a Lecturer; provided lectures and training courses for undergraduate students, Manchester program students and post graduate students. She also conducted research studies in collaboration with research teamwork in Mansoura University Hospital departments. She published 6 research articles in international Radiology journals and recognized as a Distinguished Reviewer by Elsevier publishing for reviewing more than thirty articles for publication in international journals. Email:

[email protected]
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords