alexa Malaria Transmission In Ghana: Parasite And Host Affect | 63484
ISSN: 1745-7580

Immunome Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

8th Molecular Immunology and Immunogenetics Congress

Aminata C Lo, Amoah L, Mensah K and Gyan B
Noguchi Memorial Institute for Medical Research, Ghana
Posters & Accepted Abstracts: J Immunome Res
DOI: 10.4172/1745-7580.C1.012
Abstract
The transmission of malaria parasites depends on the presence of the sexual stages (gametocytes) of P. falciparum in the blood. The probability of establishing an infection in the mosquito depends on several factors including the densities of male and female gametocytes as well as their sex ratio. This then makes it interesting to determine how gametocytes are rendered infectious as well as understand the dynamics of the development of transmission blocking antibodies which are developed against these gametocytes and also better understand how these work together to cause malaria transmission. Our objectives are: 1) To compare the prevalence of gametocytes and transmission blocking antibodies against Pfs48/45 and Pfs230; and 2) to determine cytokines profile which also influence malaria transmission in two areas with different malaria transmission intensities. Blood samples were collected from P. falciparum infected and uninfected patients living in two different malaria transmission intensity. Total IgG (and subclasses IgG1 and IgG3) and IgM levels are determined by ELISA. The levels of cytokines in the plasma (TNF, INF-γ and IL-10) are estimated by multiplex antibody. Gametocyte prevalence is measured by microscopy and qRT-PCR. Preliminary results show a variable prevalence of antibody responses against these sexual stage Pfs48/45 and pfs230 antigens. The prevalence of anti pfs230 antibodies is significantly higher in volunteers living in high malaria transmission area. However, cytokines profiling is negatively correlated with anti pfs230 antibodies production. It would be interesting to perform a correlation analysis between the effect of the prevalence of gametocytes (in progress) and the production of antibodies and cytokines.
Biography

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]line.com

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7