Management Of Skeletal Health In Patients With Early Breast Cancer Starting Aromatase Inhibitors | 33691
Journal of Cancer Science & Therapy
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Introduction: Adjuvant Aromatase Inhibitors (AIs) predispose breast cancer patients to accelerated bone loss. Consensus
guidelines recommend screening and follow of bone mineral density (BMD) with dual energy X-ray absorptiometry (DEXA)
scan in this setting. In this study we assessed the rate of adherence to these guidelines and introduced awareness measures to
Methods: We conducted a single centre, retrospective study in patients who started adjuvant AIs for invasive breast cancer.
As per World Health Organization criteria, normal BMD, osteopenia and osteoporosis were defined as T scores of >-1, -1 to
>-2.5, and ≤-2.5 respectively. In addition, we measured the frequency of therapeutic intervention at T score cut-off of <-2 as
recommended by most guidelines. Subsequently, 4 awareness sessions were conducted to encourage physicians to request a
base line DEXA scan for new patients starting adjuvant AIs. The practice was re-audited 5 months later.
Results: 554 women with early breast cancer on adjuvant hormonal therapy were identified. 367 of these patients were on
AIs and are the subject of this report. Baseline DEXA scan was performed in 188 (51.2%) patients. Of these, 24 (12.8%) had
normal BMD, 106 (56.4%) had osteopenia and 58 (30.8%) had osteoporosis. Therapeutic bisphosphonates were administered
to 83 (78.3%) osteopenic and 41 (70.7%) osteoporotic patients. 89 patients had T score <-2, of whom 67(75.3%) received
bisphosphonates. 40 out of these 89 (44.9%) had follow up DEXA scans.Twenty two new patients started AIs within the 5
months after the awareness sessions. All 22 (100%) had a DEXA scan requested
Conclusion: This study of a sizable cohort adds to limited previous observations that adherence to skeletal health guidelines
in this patient population is less than adequate. Adherence is improved dramatically by raising the awareness of relevant
Jamal Zekri has received his higher medical oncology training in Weston Park Hospital (Sheffield, England). He practiced as a consultant medical oncologist at Clatterbridge Centre for Oncology (Merseyside, England) until April 2008. Currently, he is an associate professor at Al Faisal University and the head of medical oncology services at King Faisal Specialist Hospital & Research Centre (Jeddah, Saudi Arabia). He has published more than 50 papers in peer reviewed journals and presented more than 30 abstracts of original research wok at international conferences.
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