alexa Mass Production Of Functionalized Graphene Quantum Dots And Their Application In Cancer Diagnosis And Therapy
ISSN: 2169-0022

Journal of Material Sciences & Engineering
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

Joint Conference: International Conference on DIAMOND AND CARBON MATERIALS & GRAPHENE AND SEMICONDUCTORS
July 17-18, 2017 Chicago, USA

Yanli Wang, Chenjie Yao, Lin Ding, Chenchen Li, Yanan Huang and Minghong Wu
Shanghai University, China
ScientificTracks Abstracts: J Material Sci Eng
DOI: 10.4172/2169-0022-C1-076
Abstract
Graphene quantum dots (GQDs) have garnered increasing attention because of their various alluring physicochemical properties and a wide range of potential application. However, their large-scale applications are limited by current synthetic methods that commonly produce GQDs in small amounts. Moreover, GQDs usually exhibit polycrystalline or highly defective structures and thus poor optical properties. We established a new mass-productive synthesis method of single-crystalline GQDs via a green and low-cost alkali-mediated hydrothermal molecular fusion using an active PAH molecule as a precursor. Functionalized GQDs featured excellent optical properties, strong excitonic absorption bands extending to the visible region, large molar extinction coefficients, and long-term photo-stability. Positively charged amino-GQDs could easily pass through cell membranes and localize in cell cytoplasm but show acute toxicity in vivo causing death of mice even after tail vein injection at low concentrations. Negatively charged sulfonic-GQDs could not pass through the cell membrane even after co-incubation for 48 hours under normal culture conditions. However, specific targeting of cell nuclei was found when cells were cultured in an ultrathin film with the sulfonic-GQDs. Both subcutaneous and orthotopic mice tumor models revealed that the sulfonic- GQDs showed specific targeting performance for the tumor tissues in vivo. Confocal images of frozen tumor and normal tissue sections further demonstrated the exceptional in vivo cancer-cell-nuclear-targeting capability of the sulfonic-GQDs, which showed no cancer type specificity. Both materials showed good performance for both in vitro and in vivo imaging, however, the toxicity issues of the amino-GQDs may limit their in vivo applications. Negatively charged sulfonic-GQDs showed low toxicity both in vitro and in vivo, which indicates their good potential for clinical applications.
Biography

Yanli Wang is currently working at Institute of Nanochemistry and Nanobiology of Shanghai University as Associate Professor since 2012. She obtained her PhD degree in Environmental Engineering from Shanghai University in 2010. Her research interests mainly focus on bio-effects and safety evaluation of nanomaterials and their application in bio-imaging and cancer therapy.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords