alexa Maximizing Cardiac Repair: Should We Focus On Cells Or Matrix?
ISSN: 2157-7552

Journal of Tissue Science & Engineering
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Joint Conference:3rd International Conference & Exhibition on TISSUE PRESERVATION AND BIOBANKING & 6th International Conference onTISSUE ENGINEERING AND REGENERATIVE MEDICINE
August 23-24, 2017 San Francisco, USA

Luiz C. Sampaio
Texas Heart Institute, Houston, USA
Keynote: J Tissue Sci Eng
DOI: 10.4172/2157-7552-C1-032
Abstract
Cardiac extracellular matrix (ECM) is a complex architecturally-organized mixture of proteins glycosamino-, and proteoglycans that contains an embedded vascular network. Furthermore, ECM binds growth factors that can drive vasculogenesis. In fact, during cardiac development, cell-matrix interactions give rise to regional cell fate specifications including atrial ventricular, pacemaker, vascular, and neural cells. We hypothesize that cardiac ECM plays a critical role in SC fate, location and function after myocardial injury. Using decellularized ECM from neonatal, adult and old animals, we tested the hypothesis that ECM composition and architecture provides physical, mechanical and biochemical cues that direct stem or progenitor cell fate – and show evidence that age, sex and disease state can alter those biologic cues and in turn alter cell phenotype. Furthermore, by exploring the gene expression profiles of SCs in response to infarcted heart matrix vs collagen type 1 or non-infarcted matrix, we have begun to define cues that may begin to explain clinical outcomes after cell therapy. We have also transplanted repopulated and “naked” ECM in vivo either as a cardiac patch after infarction or as a whole heart to investigate SC recruitment and differentiation in response to acellular or recellularized ECM. Finally, we are convinced that creating and being able to manipulate the right environment can be more valuable than engineering cells. Our perfusion-based method to remove cells from myocardium giving rise to decellularized ECM (dECM) with intact micro and macrostructure, and a patent vascular tree has been proved to be the perfect environment for stem cells.
Biography

Dr. Luiz C. Sampaio has devoted his entire career to reducing the burden of cardiovascular disease, first as a cardiovascular surgeon then as a regenerative medicine researcher. In his current positions as associate medical director for the Department of Regenerative Medicine Research and director of the Cullen Cardiovascular Research Laboratories at Texas Heart Institute, he is able to apply his medical and surgical skills to developing new approaches to preventing, diagnosing, and treating heart disease.

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version