Aim:Study was undertaken to evaluate and compare the neurodegenerative defending potential of Curcumin, De-
methoxycurcumin & Bis-demethoxycurcumin on 6-hydroxy dopamine induced animal Parkinsonism model.
Material and Method:
Isolated curcuminoids were administered (30 mg/kg) for three weeks followed by unilateral injection
of 6-hydroxydopamine on 22
day (10μg/2μl) into the right striatum leading to extensive loss of dopaminergic cells. The
behavioral observations (apomorphine induced rotations, motor coordination & locomotor activity), biochemical markers
(Malondialdehyde, Glutathione, Glutathione reductase, Glutathione peroxidase, Superoxide dismutase & Catalase), Dopamine
receptor binding assay and tyrosine hydroxylase immunohistochemistry were evaluated after three weeks of leison.
Results & Discussion:
6- hydroxydopamine induced neurodegeneration is associated with an antioxidant deficit and deranged
levels of biochemical markers. The increase in apomorphine-induced rotations and deficits in locomotor activity & muscular
coordination due to 6- hydroxydopamine injection were significantly restored in curcuminoids pretreated groups with Curcumin
showing maximal recuing effect as compared to protective effects of De-methoxycurcumin and Bis-demethoxycurcumin. Pretreated
animals showed significant protection against neuronal degeneration compared to leison animals by normalizing the deranged
levels of biomarkers and showed the effectivity in the order Curcumin > De-methoxycurcumin
The same order of potency was observed in D
receptors binding assay and tyrosine hydroxylase immunohistochemistry study.
Curcuminoids appears to shield progressive neuronal degeneration from increased oxidative attack in 6-OHDA lesioned rats
through its free radical scavenging, MAO-B inhibiting and DA enhancing capabilities in the sequence of efficacy; Curcmin >
De-methoxycurcumin > Bis-demethoxycurcumin. Further, curcuminoids may have potential utility in treatment of many more
oxidative stress induced neurodegenerative disorders.
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