alexa Mechanism Of Cellular Immune Response To Strange Objects
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

3rd International Conference and Exhibition on Clinical & Cellular Immunology
September 29-October 01, 2014 DoubleTree by Hilton Baltimore-BWI Airport, USA

Ponizovskiy M R
Accepted Abstracts: J Clin Cell Immunol
DOI: 10.4172/2155-9899.S1.019
Abstract
Natural Killer (NK) cells are dominant effectors of early host defense. Their activity depends on balance of signals from activation and inhibition receptors. Various soluble factors, including cytokines have an influence on phenotype of NK cells.To investigate this effect, we used pro-inflammatory and anti-inflammatory cytokines. IFN-γ induces Class II major histocompatibility complex (MHC) molecule expression. IL-8 basic functions include chemotaxis, activation and the induction of neutrophil infiltration. IL-10 is an anti-inflammatory cytokine with multidirectional effects in immunoregulation and inflammation. Assay was performed using NK-92MI natural killer cell line. Cells were treated with 3 different doses of cytokines (IFN-γ, IL-8, IL-10, separately) for 24 hours. Surface molecules expression was assessed by flow cytometric analysis using fluorochrome-conjugated mABs and FACSC. IFN-γ significantly (p<0.05) upregulated expressions of KIR2DL1, KIR3DL1, CD11a, CD11b, CD18, CD29, CD44 (dose-dependent), CD47 (dose-dependent), CD184 (dose-dependent), CD49d and CD54. Cells stimulated byIL-8 showed significally higher expression level ofCD29. However, IL-8 downregulated KIR2DL3, KIR2DL4, KIR3DL1 (dose-dependent), KIR2DS4, CD11b (dose-dependent), CD18, CD49d (dose-dependent), CD44 and CD58. Significantly increased expression of CD47, CD58 (dose-dependent) and CD49 was discovered in cells treated with IL- 10, but expression of KIR2DL1, KIR2DL3, CD29, CD44, and CD184 was significally decreased.
Biography
Larisa Viazmina is a five-year student of biotechnology faculty of Saint Petersburg Chemical Pharmaceutical Academy. She is laboratory research assistant in immunology department of D. O. Ott Research Institute of Obstetrics and Gynecology. Her research interests are related to reproductive immunology, mainly preeclampsia and NK cells.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords