alexa Mechanistic Study Of Phlorofucofuroeckol A For The Induction Of Apoptosis In Human Colorectal Cancer Cells
ISSN: 2376-0419

Journal of Pharmaceutical Care & Health Systems
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10TH Asia-Pacific Pharma Congress
May 08-10, 2017 Singapore

Jin Boo Jeong
Andong National University, South Korea
Posters & Accepted Abstracts: J Pharma Care Health Sys
DOI: 10.4172/2376-0419-C1-021
Abstract
Phlorofucofuroeckol A (PFF-A) as one of the phlorotannins found in the brown algae has been reported to exert anti-cancer property. However, the molecular mechanism for anti-cancer effect of PFF-A has not been known. Activating transcription factor 3 (ATF3) has been reported to be associated with apoptosis in colorectal cancer. The present study was performed to investigate the molecular mechanism by which PFF-A stimulates ATF3 expression and apoptosis in human colorectal cancer cells. PFF-A decreased the cell viability through an apoptosis in human colorectal cancer cells. PFF-A increased ATF3 expression through regulating transcriptional activity. The responsible cis-element for ATF3 transcriptional activation by PFF-A was CREB located between -147 to -85 of ATF3 promoter. Inhibitions of p38, JNK, GSK3β and IκK-α blocked PFF-A-mediated ATF3 expression. ATF3 knockdown by ATF3 siRNA attenuated the cleavage of PARP by PFF-A, while ATF3 overexpression increased PFF-A-mediated cleaved PARP. These results suggest that PFF-A may exert anti-cancer property through inducing apoptosis through ATF3-mediated pathway in human colorectal cancer cells.
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