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Melatonin Attenuates Arsenic-induced Adrenal Toxicity In Mice | 5811
ISSN: 2161-0495

Journal of Clinical Toxicology
Open Access

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Melatonin attenuates arsenic-induced adrenal toxicity in mice

International Toxicology Summit & Expo

Dimple Damore

ScientificTracks Abstracts: J Clinic Toxicol

DOI: 10.4172/2161-0495.S1.002

E xposure to toxic metals remains a widespread occupational and environmental problem in world. Arsenic is a ubiquitous element in the environment causing oxidative burst in the exposed individuals leading to tissue damage. Antioxidants have long been known to reduce the free radical-mediated oxidative stress. Therefore, the present study was designed to investigate whether administration of melatonin (10 mg/kg b.w, i.p) to arsenic intoxicated mice (0.5 and 1.0 mg/kg b.w, po) for 30 days affords protection against the oxidative stress caused by the metalloid. Daily oral administration of arsenic trioxide for 30 days induced a marked dose-related enhancement of lipid peroxidation and degeneration of adrenal tissue indicating significant induction of oxidative damage. Additional evidence such as depletion in reduced glutathione levels and alterations in enzymic antioxidant defences like superoxide dismutase, catalase and glutathione peroxidase in adrenal gland suggested induction of oxidative stress. Concomitant administration of melatonin with arsenic exposed mice showed a decrease in the level of lipid peroxidation, and enhanced levels of glutathione, activities of superoxide dismutase, glutathione peroxidase and catalase to near normal. These finding suggest that melatonin is potentially capable of limiting adrenal gland damage by protecting the antioxidant system in arsenic-intoxicated mice

Dimple Damore received M.Phil (2003) and Doctorate (2008) in toxicology from School of Sciences, Gujarat University, Ahmadabad, India. She, as a full time tenured associate professor has been teaching Zoology in Bhavan?s Sheth R.A. College of Science, Ahmadabad, India since 1995. Currently, she is Head of Department for zoology. She teaches undergraduate students biochemistry, mammalian physiology, embryology, toxicology, and environmental studies. She is member of Gujarat University Board of Studies in zoology. She conducts research in biological sciences with emphasis on environmental toxicology, and has published papers in professional journals. She has attended many seminars, workshops, orientation and refresher courses, national and international conferences in biological sciences. She has made oral and poster presentations at national and international conferences