alexa Meta-analysis Of Transcriptional Profiles In Cancer For Prognosis Prediction And Metastatic Gene Identification
ISSN: 2161-1017

Endocrinology & Metabolic Syndrome
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

2nd International Conference on Endocrinology
October 20-22, 2014 DoubleTree by Hilton Hotel Chicago-North Shore, USA

Yajun Yi
ScientificTracks Abstracts: Endocrinol Metab Synd
DOI: 10.4172/2161-1017.S1.005
Abstract
With thousands of cancer gene expression datasets deposited in public databases, we have developed a meta-analysis strategy called EXALT (EXpression AnaLysis Tool). It allows us to perform unique meta-analyses of gene-expression profiles that are independent of technology platforms and to discover recurrent and reliable gene expression signatures for cancer prognosis prediction and functional gene identification. We have clustered heterogeneous signatures from 223 public datasets containing 10,581 breast cancer samples. The signatures were systematically organized by their common data elements and assembled into a new signature data type called meta-signature. We identified a specific meta-signature consisting of 50 genes (BRmet50) that is robustly predictive of cancer prognosis in 6,011 breast cancer patients from 21 different breast cancer datasets as well as in other malignancies including lung and prostate cancer. These findings illustrate the value of BRmet50 in breast cancer prognosis. Furthermore, we have established a translational model by combining a meta-analysis of public cancer gene-expression profiles with functional validation approaches. From the candidate genes encoded in BRmet50, we identified SPARCL1 as a metastasis-suppressor. Loss of SPARCL1 expression was previously reported during the clinical progression of prostate cancer. We demonstrated that SPARCL1 reconstitution suppresses tumor cell migration and invasiveness in vitro and tumor metastatic growth in vivo, conferring improved survival in xenograft mouse models. Further investigations on SPARCL1 mechanisms, our results indicate that changes in the AKT signaling pathway correlates with SPARCL1 suppression of cancer cell invasion, and a truncated SPARCL1 mutant inhibits cancer cell invasion
Biography
Yajun Yi has completed his PhD from University Manitoba, Canada and postdoctoral studies from Northwestern University School of Medicine. He received Howard Temin Award from the National Cancer Institute. He has published more than 30 papers in peer-reviewed and obtained two patents.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords