alexa
Reach Us +44-1477412632
Metabolic Acidosis Status And Mortality In Patients On The End Stage Of Renal Disease | 53819
ISSN: 2161-0959

Journal of Nephrology & Therapeutics
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Metabolic acidosis status and mortality in patients on the end stage of renal disease

9th International Conference on Nephrology: Kidney & Therapeutics

Vaia D Raikou

National and Kapodistrian University of Athens, Greece

Posters & Accepted Abstracts: J Nephrol Ther

DOI: 10.4172/2161-0959.C1.031

Abstract
Introduction-Aim: Uncorrected metabolic acidosis leads to higher death risk in dialysis patients. We observed the relationship between metabolic acidosis status and mortality rate in patients on renal replacement therapy during a median follow up time of 60 months. Methods: We studied 76 patients on on-line hemodiafiltration. Dialysis adequacy was defined by Kt/V for urea. Framingham risk score (FRS) points were used to determine the 10-year risk for coronary heart disease. We examined the impact of high or low serum bicarbonate concentrations on mortality rate and on 10-year risk for coronary heart disease via the Kaplan-Meier method. Cox’s model was used to evaluate a combination of prognostic variables, such as dialysis adequacy defined by Kt/V for urea, age and serum bicarbonate concentrations. Results: We divided the enrolled patients in 3 groups according to serum bicarbonate concentrations (<20 mmol/L, 20- 22 mmol/L and >22 mmol/L). Kaplan-Meier survival curve for the impact of serum bicarbonate concentrations on overall mortality was found significant (log-rank=7.8, p=0.02). The prevalence of serum bicarbonate less or more than 20 mmol/L on high FRS ( >20%) by Kaplan-Meier curve was also found significant (log-rank=4.9, p=0.02). Cox’s model revealed significant predictive effect of serum bicarbonate on overall mortality (p=0.006, OR=1.5, 95% CI=1.12-1.98) in combination to Kt/V for urea and age. Conclusion: Uncorrected severe metabolic acidosis, defined by serum bicarbonate concentrations less than 20 mmol/L, is associated with 10-year risk for coronary heart disease more than 20% and high overall mortality in patients on renal replacement therapy.
Biography

Email: [email protected]

Top